ReviewFrontiers in immunology2025
Unraveling the Mystery of Breast Cancer Dormancy: Insights into Genetic, Receptor, and Cellular Interactions Driving Late Recurrence.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cytokine Regulation of the Bone Pre- and Metastatic Niches: Implications for Breast Cancer Dormancy.Cells · 2026Review
- "Immune senescence and dormant tumor cells: reconceptualizing breast cancer recurrence as an affliction of aging and chronic inflammation".Annals of medicine and surgery (2012) · 2026Review
- Regulating the dormancy of cancer stem cells: a novel approach to preventing cancer relapse.Cell death & disease · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late recurrence of breast cancer poses a considerable threat to patient survival, often attributed to breast cancer dormancy. Dormancy, characterized by cancer cells remaining quiescent for extended periods, is influenced by genetic factors and modifications that directly impact cellular phenotype. Alterations in gene expression dynamically shape cellular behavior, often mediated through receptor signaling pathways. Moreover, interactions within the tumor microenvironment play a pivotal role, fostering either cancer cell dormancy or promoting their escape from dormancy. This review endeavors to provide a comprehensive synthesis of recent advancements in understanding breast cancer dormancy across genetic, receptor molecular, and cellular dimensions. By elucidating the intricate mechanisms underlying dormancy, we aim to shed light on potential therapeutic strategies to prevent late recurrences. Furthermore, we anticipate future research directions that may uncover novel insights into this complex phenomenon, ultimately improving patient outcomes and refining clinical management strategies for breast cancer recurrence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.