ArticleWorld journal of gastrointestinal oncology2025
Quantitative immunohistochemistry analysis of pancreatic adenocarcinoma upregulated factor expression in pancreatic cancer and its prognostic significance.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review).International journal of molecular medicine · 2026Review
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8 authors.
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Abstract
backgroundAmong all solid tumors, pancreatic ductal adenocarcinoma (PDAC) is characterized by markedly poor survival outcomes, reflecting its high lethality, primarily as a result of late-stage diagnosis and limited treatment options. Pancreatic adenocarcinoma upregulated factor (PAUF) displays elevated expression in PDAC compared to non-neoplastic pancreatic samples and is involved in promoting tumor development. However, its exact diagnostic and prognostic significance remains unclear. This study aimed to assess the clinical relevance of PAUF expression in PDAC. We hypothesized that higher PAUF expression is associated with more aggressive clinicopathological features and poorer patient outcomes.
aimTo investigate the expression of PAUF in PDAC and its value as a diagnostic and prognostic biomarker.
methodsPAUF expression levels were assessed using immunohistochemistry in tumor tissues from 93 patients with PDAC. Staining intensity and the proportion of tumor cells showing PAUF positivity were assessed to categorize patients into low and high PAUF expression groups. Associations between PAUF expression and clinicopathological characteristics or survival outcomes were analyzed. Public datasets (The Cancer Genome Atlas, Genotype-Tissue Expression, and Clinical Proteomic Tumor Analysis Consortium) were employed to validate differences in PAUF expression in PDAC at mRNA and protein levels.
resultsPAUF expression was observed in 82.8% of samples, primarily localized within the cytoplasm of tumor cells. High PAUF expression showed a significant correlation with metastasis to lymph nodes (78.4%,
conclusionPAUF is a promising biomarker for tumor progression and prognosis in PDAC, with potential clinical utility in early diagnosis and the development of targeted therapies.
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