Evidence map›Paper›PMID 40977665›Full record

ArticleWorld journal of gastrointestinal oncology2025

Prognostic factors and efficacy of postoperative chemotherapy in patients with gastric cancer with positive peritoneal cytology after gastrectomy.

Yoichi Sugiyama, Kazuaki Tanabe, Senichiro Yanagawa, Hirofumi Tazawa, Kazuhiro Toyota, Mikihiro Kano, Toshihiro Misumi, Masayuki Shishida, Keisuke Okano, Ryuichi Hotta and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07478107 (Application of the One-step Nucleic Acid Amplification), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07478107 completednot on this map

Application of the One-step Nucleic Acid Amplification (OSNA) Assay to Detect Free Cancer Cells in the Peritoneal Washing of Gastric and Colon Cancer Patients

Typeobservational_patient_registrySponsorUniversity of Campania Luigi VanvitelliRan2024 to 2026Enrolled108ConditionsPeritoneal Carcinomatosis
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yoichi SugiyamaDepartment of Gastrointestinal Surgery, JA Hiroshima General Hospital, Hatsukaichi 738-8503, Japan.
Kazuaki TanabeDepartment of Perioperative and Critical Care Management, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima 734-8551, Japan. ktanabe2@hiroshima-u.ac.jp.
Senichiro YanagawaDepartment of Surgery, JA Onomichi General Hospital, Onomichi 722-8508, Japan.
Hirofumi TazawaDepartment of Surgery, Kure Medical Center, Chugoku Cancer Center, Kure 737-0023, Japan.
Kazuhiro ToyotaDepartment of Surgery, Hiroshima Memorial Hospital, Hiroshima 730-0802, Japan.
Mikihiro KanoDepartment of Surgery, Hiroshima City North Medical Center Asa Citizens Hospital, Hiroshima 731-0293, Japan.
Toshihiro MisumiDepartment of Gastroenterological Surgery, Hiroshima Prefectural Hospital, Hiroshima 734-8530, Japan.
Masayuki ShishidaDepartment of Surgery, JR Hiroshima Hospital, Hiroshima 732-0057, Japan.
Keisuke OkanoDepartment of Surgery, Miyoshi Central Hospital, Miyoshi 728-8502, Japan.
Ryuichi HottaDepartment of Surgery, NHO Higashihiroshima Medical Center, Higashihiroshima 739-0041, Japan.
Hiroshi OtaDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.
Yasuhiro ImaokaDepartment of Surgery, JA Yoshida General Hospital, Akitakata 731-0595, Japan.
Toshikatsu FukudaDepartment of Surgery, Chugoku Rosai Hospital, Kure 737-0193, Japan.
Shinya TakahashiDepartment of Surgery, Graduate School of Biochemical and Health Science, Hiroshima University, Hiroshima 734-8551, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8551, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeritoneal lavage cytology-positive (CY1) gastric cancer (stage IV) has a poor prognosis, though some cases fare better. Therefore, identifying prognostic factors and an optimal treatment strategy is crucial.

aimTo investigate prognostic factors in patients with gastric cancer who underwent gastrectomy with CY1, and to evaluate the optimal postoperative chemotherapy regimen.

methodsThis multicenter retrospective cohort study analyzed prognostic factors and postoperative chemotherapy in patients with CY1 gastric cancer who underwent gastrectomy, excluding those with macroscopic peritoneal dissemination. Data from 13 institutions (2015-2019) were reviewed.

resultsOverall, 82 patients met the inclusion criteria. The median overall survival was 22.8 months, and diffuse-type histology and the absence of postoperative chemotherapy were identified as independent poor prognostic factors. The 5-year survival rate was 82.4% for those receiving fluoropyrimidine plus docetaxel/oxaliplatin

conclusionDiffuse-type histology and the absence of postoperative chemotherapy influence the prognosis of patients with CY1 gastric cancer. Combination therapy with oxaliplatin or docetaxel may enhance the treatment intensity and improve survival outcomes after gastrectomy.

Indexed as

Cancer statisticsChemotherapyGastric cancerPeritoneal lavage cytology-positivePrognostic factorSurvivalTreatment strategy

Identifiers

PMID40977665
PMCPMC12444290

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Registered trials

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