ArticleWorld journal of gastrointestinal oncology2025
Relationship between uric acid and colon cancer risk: Dose-response analysis and mechanisms.
Article in World journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
backgroundUric acid (UA), a key antioxidant metabolite, demonstrates dual roles in cancer. Unfortunately, studies on its role in colon cancer risk are uncommon, and the limited results are inconsistent.
aimTo elucidate the association between UA and colon cancer risk and its mechanisms.
methodsMultivariate logistic regression analysis evaluated the association between UA levels and colon cancer risk. Non-linear relationships were illustrated using restricted cubic splines. The threshold effect was performed to identify cut-off points. Human colon cancer cell lines (HCT-116 and HT29) were exposed to UA for 48 hours. Cell viability was assessed
resultsAfter adjusting for potential confounders, an inverse association was observed between UA and colon cancer risk (odds ratio = 0.65,
conclusionUA acts as a protective agent against colon cancer by inhibiting cell proliferation and migration through increased reactive oxygen species production and modulation of the PI3K/protein kinase B/mammalian target of rapamycin pathway.
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