ArticleMolecular biology and evolution2025
From Rabl-like Architecture to Chromosome Territories: A Conserved Developmental Transition in Animal Genomes.
Article in Molecular biology and evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Vertebrate Genomes Project Phase I: A global reference genome resource.bioRxiv : the preprint server for biology · 2026Article
- Spatial Chromatin Organization Across the Cell Cycle: Insights from Auxin-Inducible Protein Depletion.Cells · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
In eukaryotes, chromosomes can be arranged with centromeres and/or telomeres clustered at opposite poles of the nucleus (Rabl-like, RBL) or as discrete spatial domains (chromosome territory, CT). These patterns were thought to be species specific, possibly linked to the presence or absence of condensin II subunits. Time-series embryonic chromatin maps from three distantly related animals reveal that RBL and CT reflect cell state rather than species identity, and a conserved RBL-to-CT transition has occurred during development. This shift is not significantly correlated with condensin II gene expression, but may be influenced by the genomic distribution of repetitive sequences. In late developmental stages, long-range cis- and trans-interactions between active A1 subcompartments progressively intensify, ultimately establishing CT as the dominant architecture. These results uncover a conserved, developmentally regulated reorganization of 3D genome structure across animals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.