ArticleHuman vaccines & immunotherapeutics2025
Astragalus polysaccharide and aluminum adjuvant synergize to amplify immune responses induced by a recombinant COVID-19 vaccine.
Article in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
10 authors.
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Abstract
Despite extensive surveillance and intervention efforts, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a significant global public health threat. Vaccination is recognized as the most effective strategy for controlling SARS-CoV-2 infection. However, the immunogenicity of current COVID-19 vaccines, particularly protein subunit vaccines, requires further enhancement, highlighting the development of novel adjuvants to improve vaccine efficacy. In this study, we systematically evaluated the immunoenhancing effects of Astragalus polysaccharides (APS), a natural adjuvant, on SARS-CoV-2 recombinant protein vaccines using a BALB/c mouse immunization model. Our results demonstrate that APS significantly augments COVID-19 vaccine immunogenicity by promoting antibody production, activating antigen-specific IgG
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