Evidence map›Paper›PMID 40977276›Full record

ArticleAging cell2025

Dual-Lineage Chondrocyte-Like Cells in the Nucleus Pulposus of Aging Intervertebral Discs Are Accelerated by Hedgehog Signaling Inactivation.

Lei Zhang, Chunmei Xiu, Hongji You, Jianquan Chen

Abstract read
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lei ZhangOrthopedic Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Chunmei XiuSchool of Medicine, Hangzhou City University, Zhejiang, Hangzhou, China.
Hongji YouOrthopedic Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, China.
Jianquan ChenSchool of Medicine, Hangzhou City University, Zhejiang, Hangzhou, China.ORCID 0000-0002-0468-6287

Funding

the National Natural Science Foudation of China 81772294the National Natural Science Foudation of China 82272543
6 · The paper itself

Abstract

Intervertebral disc (IVD) degeneration, a major contributor to chronic low back pain, is characterized by the age-related replacement of notochord-derived nucleus pulposus cells (NPCs) with chondrocyte-like or fibrotic cells (CLCs). However, the cellular origins of CLCs and mechanisms driving their emergence remain contentious. Using genetic lineage tracing with Shh-Cre and Gli1-CreER

Indexed as

AgingCell LineageChondrocytesHedgehog ProteinsIntervertebral DiscNucleus PulposusSignal TransductionAnimalsHumansIntervertebral Disc DegenerationMiceZinc Finger Protein GLI1Hedgehog ProteinsZinc Finger Protein GLI1chondrocyte‐like cellshedgehog signalingintervertebral disc degenerationlineage tracingnucleus pulposus

Identifiers

PMID40977276
PMCPMC12611273

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.