ArticleOrganic letters2025
Deacylative Polyfluoroarylation via C-C Cleavage of Alkyl Ketones.
Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
Polyfluoroarenes often exist in functional molecules; however, construction of alkyl-polyfluoroaryl bonds remains nontrivial, and the current approaches exhibit various limitations. Here we report the first deacylative polyfluoroarylation of readily available methyl ketones, enabled by aromatization-driven C-C bond cleavage. This method allows efficient synthesis of both primary and secondary alkyl-substituted polyfluoroarenes under simple and convenient conditions, demonstrating excellent functional group tolerance and generality. The preliminary mechanistic study suggests the involvement of direct addition of the alkyl radical intermediate, generated after the C-C bond cleavage, to the polyfluoroarene, followed by either a single-electron transfer (SET) or hydrogen-atom transfer (HAT) process with the prearomatic intermediate (PAI).
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