Evidence map›Paper›PMID 40977211›Full record

SynthesisSexual health2025

Barriers and facilitators to engagement with the PrEP care continuum among sexual minority men in China: a systematic review.

Chenglin Hong, Liying Wang, Yilin Wang, Yuqing Wang, Lingxiao Chen, Frank Y Wong, Jane M Simoni, Ian W Holloway, Steven A John

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Sexual health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chenglin HongSchool of Social Work, University of Connecticut, Hartford, CT, USA; and Institute for Collaboration on Health, Intervention, and Policy, University of Connecticut, Storrs, CT, USA.
Liying WangCollege of Nursing, Florida State University, Tallahassee, FL, USA.
Yilin WangBrown School of Social Work, Washington University in St. Louis, St. Louis, MO, USA.
Yuqing WangGraduate Group in Epidemiology, University of California, Davis, CA, USA.
Lingxiao ChenDepartment of Human and Organizational Development, Vanderbilt University, Nashville, TN, USA.
Frank Y WongCollege of Nursing, Florida State University, Tallahassee, FL, USA; and Center for Population Sciences and Health Equity, Florida State University, Tallahassee, FL, USA.
Jane M SimoniDepartment of Psychology, University of Washington, Seattle, WA, USA.
Ian W HollowaySchool of Nursing, University of California Los Angeles, Los Angeles, CA, USA.
Steven A JohnDepartment of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN, USA.

Funding

Scientific and Technical CoreP2CHD041022 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Martha Jane Bailey · 2016 to 2026
$6.9M
NICHD NIH HHS P2C HD041022
6 · The paper itself

Abstract

Sexual minority men (SMM) in China are disproportionately affected by the HIV epidemic, yet utilization of HIV prevention services, such as pre-exposure prophylaxis (PrEP), remains low. This systematic review summarizes the barriers and facilitators to the PrEP care continuum among Chinese SMM using thematic analysis. Following PRISMA guidelines, a comprehensive literature search was conducted in English and Chinese databases, including PubMed, EMBASE, Web of Science, PsycINFO, CINAHL, CNKI and WanFang. From 820 records, 50 studies met inclusion criteria, revealing five key themes: (1) sexual behaviors and perceived HIV risk; (2) PrEP-related stigma and homophobia; (3) history of HIV and other STI care engagement; (4) perceptions of PrEP efficacy, side-effects and adherence, and (5) structural and access barriers, including cost, health insurance and residential status. Improving PrEP uptake among Chinese SMM requires addressing sexual risk behaviors, societal stigma and structural barriers. Comprehensive education around PrEP, stigma reduction and financial support are crucial. Targeted public health initiatives and policy changes are necessary to enhance PrEP awareness, accessibility and adherence among Chinese SMM. Additionally, integrating PrEP education into existing HIV/STI care frameworks, and fostering supportive environments within healthcare settings can further mitigate barriers. There is a need to explore and promote alternative PrEP modalities, including on-demand (event-driven) PrEP and long-acting injectable PrEP, to better meet the diverse needs of Chinese SMM. Collaboration between government, healthcare providers and community organizations is essential to develop and implement effective strategies for increasing PrEP uptake and ensuring sustained HIV prevention efforts among Chinese SMM.

Indexed as

Continuity of Patient CareHealth Services AccessibilityHIV InfectionsHomosexuality, MalePatient Acceptance of Health CarePre-Exposure ProphylaxisSexual and Gender MinoritiesChinaHumansMaleSocial Stigma

Identifiers

PMID40977211
PMCPMC12704366

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.