Evidence map›Paper›PMID 40977146›Full record

ArticleEuropean journal of immunology2025

TNF Production or TNFR2 Expression Characterize Distinct States of Regulatory T Cells that Cooperate in Treg Expansion in Cancer and Chronic Inflammation.

Gloria Tucci, Ilenia Pacella, Alessandra Pinzon Grimaldos, Alessandra Rossi, Ilenia Cammarata, Marta Zagaglioni, Giovanna Peruzzi, Valentina Tirelli, Massimo Sanchez, Giuseppe Pietropaolo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Decoding TNF receptor superfamily control of CD4Cell communication and signaling : CCS · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Gloria TucciDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Ilenia PacellaDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Alessandra Pinzon GrimaldosDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Alessandra RossiDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Ilenia CammarataDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Marta ZagaglioniDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Giovanna PeruzziCentre For Life Nano- & Neuro-Science, Fondazione Istituto Italiano Di Tecnologia (IIT), Rome, Italy.
Valentina TirelliCore Facilities, Istituto Superiore Di Sanità, Rome, Italy.
Massimo SanchezCore Facilities, Istituto Superiore Di Sanità, Rome, Italy.
Giuseppe PietropaoloIRCCS Neuromed, Pozzilli, Italy.
Francesca SozioDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Annalisa Del PreteDepartment of Molecular and Translational Medicine, University of Brescia, Italy; IRCCS Humanitas Research Hospital, Milan, Italy.
Valerio LicursiInstitute of Molecular Biology and Pathology (IBPM), National Research Council (CNR) of Italy c/o Department of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Italy.ORCID 0000-0002-8172-1437
Vincenzo BarnabaDepartment of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.
Silvia PiconeseDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-9685-5227

Funding

Fondazione AIRC per la ricerca sul cancro ETS Accelerator Award Project 620 Id. 22794 (VB)Fondazione AIRC per la ricerca sul cancro ETS IG-19939 (VB)Fondazione AIRC per la ricerca sul cancro ETS IG-2017 19784 (SP)Fondazione AIRC per la ricerca sul cancro ETS IG-2022 27070 (SP)Fondazione Italiana Sclerosi Multipla cod. 2015/R-single/04 (VB)Fondazione Italiana Sclerosi Multipla cod. 2019/R-single/053 (VB)Istituto Pasteur-Fondazione Cenci Bolognetti Call 2019 under 45 (SP)Ministero della Salute Ricerca Finalizzata GR-2019-12368551 (SP)NextGenerationEU PNRR-MAD-2022-12375947(GPi)
6 · The paper itself

Abstract

TNF is a pleiotropic cytokine with immunomodulatory functions mediated by its interaction with the receptor TNFR2, highly expressed by Tregs. However, Tregs can also produce TNF, and an autocrine TNF-TNFR2 loop has been proposed. Here, we describe that both human and mouse Tregs produce TNF in physiological conditions, in several mouse organs, and in mouse models of chronic inflammation and cancer. However, TNF production and TNFR2 expression are differentially distributed: indeed, TNFR2

Indexed as

InflammationNeoplasmsReceptors, Tumor Necrosis Factor, Type IIT-Lymphocytes, RegulatoryTumor Necrosis Factor-alphaAnimalsChronic DiseaseForkhead Transcription FactorsHumansMiceMice, Inbred C57BLForkhead Transcription FactorsReceptors, Tumor Necrosis Factor, Type IITnfrsf1b protein, mouseTumor Necrosis Factor-alphaoxidative stressTNFTNFR2Tregtumor microenvironment

Identifiers

PMID40977146
PMCPMC12451257

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.