Evidence map›Paper›PMID 40977128›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging

Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke.

Hamza Adel Salim, Dhairya A Lakhani, Aneri Balar, Mona Shahriari, Aakanksha Sriwastawa, Andrew Cho, Adam A Dmytriw, Adrien Guenego, Elisabeth B Marsh, Hanzhang Lu and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Prolonged Venous Transit Is Associated With Unfavorable Outcomes in Anterior Circulation Distal Medium Vessel Stroke.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Hamza Adel SalimDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-5208-8425
Dhairya A LakhaniDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-7577-1887
Aneri BalarDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Mona ShahriariDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Aakanksha SriwastawaDepartment of Radiology, University of Cincinnati, Cincinnati, Ohio, USA.
Andrew ChoDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Adam A DmytriwNeuroendovascular Program, Massachusetts General Hospital, Harvard University, Boston, Massachusetts, USA.
Adrien GuenegoDepartment of Diagnostic and Interventional Neuroradiology, Erasme University Hospital, Brussels, Belgium.ORCID https://orcid.org/0000-0001-7281-1652
Elisabeth B MarshDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Hanzhang LuDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Risheng XuDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Rich LeighDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Gaurang ShahDepartment of Radiology, University of Michigan, Ann Arbor, Michigan, USA.
Sijin WenDepartment of Epidemiology and Biostatistics, West Virginia University, Morgantown, West Virginia, USA.
Gregory W AlbersDepartment of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, California, USA.
Argye E HillisDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Rafael LlinasDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.
Kambiz NaelDepartment of Radiology & Biomedical Imaging, University of California, San Francisco, California, USA.ORCID https://orcid.org/0000-0002-4194-9488
Max WintermarkDepartment of Neuroradiology, MD Anderson Medical Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-1001-5591
Jeremy J HeitDepartment of Interventional Neuroradiology, Stanford Medical Center, Palo Alto, California, USA.
Tobias D FaizyDepartment of Radiology, Neuroendovascular Program, University Medical Center Münster, Münster, Germany.
Vivek S YedavalliDivision of Neuroradiology, Department of Radiology, Johns Hopkins Medical Center, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-2450-4014

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942NIH HHS 5U54GM104942-08
6 · The paper itself

Abstract

background and purposeDistal medium-vessel occlusion (DMVO) strokes represent a significant proportion of acute ischemic stroke cases, yet optimal management remains unclear. Prolonged venous transit (PVT), a marker of poor venous outflow, has been associated with worse outcomes in large-vessel occlusion strokes, but its role in DMVO is unknown.

methodsIn a retrospective study, consecutive patients with anterior-circulation DMVO, defined as occlusions in the M2-M4 segments of the middle cerebral artery or the anterior cerebral artery. PVT status was determined on pretreatment time-to-maximum perfusion maps by identifying ≥10-s delays in either the posterior superior sagittal sinus or the torcula. Baseline characteristics, imaging findings, and interventions were collected. The primary outcome was a 90-day modified Rankin Scale (mRS) score of 0-2.

resultsAmong 77 patients (median age 70 years, 56% female), 18 (23%) had PVT. Median admission National Institutes of Health Stroke Scale scores were 11 (interquartile range, 7-15), and intravenous thrombolysis was administered to 35% of patients. Patients with PVT+ were less likely to achieve mRS 0-2 at 90 days (adjusted odds ratio, 0.14; 95% confidence interval, 0.02-0.85; p = 0.046). There were no significant differences in rates of hemorrhagic transformation or mortality.

conclusionsPVT is independently associated with unfavorable functional outcomes in anterior-circulation DMVO. These findings suggest PVT may serve as a prognostic indicator and could inform treatment decisions in this challenging stroke subtype.

Indexed as

Cerebral VeinsIschemic StrokeAgedAged, 80 and overCerebrovascular CirculationFemaleHumansMaleMiddle AgedRetrospective Studiesperfusion imagingprolonged venous transitstroke

Identifiers

PMID40977128
PMCPMC12451256

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.