Evidence map›Paper›PMID 40977112›Full record

ReviewBrain and behavior2025

Neurostructural Differences Associated With Prodromal Mania Symptoms in Children.

Camille Archer, Amy Milewski, Hee Jung Jeong, Gabrielle E Reimann, E Leighton Durham, Antonia N Kaczkurkin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Camille ArcherDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Amy MilewskiDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Hee Jung JeongDepartment of Psychology, Sogang University, Seoul, South Korea.
Gabrielle E ReimannDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
E Leighton DurhamDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Antonia N KaczkurkinDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-0943-3094

Funding

Delineating neurobiological heterogeneity in internalizing symptoms using machine learning and deep phenotypingR00MH117274 · NIMH · VANDERBILT UNIVERSITY · PI KACZKURKIN, ANTONIA · 2019 to 2021
$729k
Brain and Behavior Research Foundation 30891National Science Foundation 1937963NIMH NIH HHS R00MH117274NIMH NIH HHS T32MH18921
6 · The paper itself

Abstract

introductionProdromal symptoms of mania in children are predictive of the later development of bipolar disorder; yet, the neurostructural correlates of these early symptoms remain poorly understood. This study aimed to investigate the association between prodromal mania symptoms and brain structure in a large cohort of children.

methodsWe analyzed data from 10,662 nine- to 10-year-old children from the Adolescent Brain Cognitive Development (ABCD) Study, employing structural equation modeling to examine the concurrent and longitudinal associations between prodromal mania symptoms and cortical and subcortical gray matter volume.

resultsAfter adjusting for multiple comparisons and controlling for age, sex, scanner model, socioeconomic status, and medication use, we found that baseline mania symptoms were associated with reduced gray matter volume across both cortical and subcortical areas, suggesting a global effect. These findings were further supported by the loss of these effects when total intracranial volume was included as an additional covariate, suggesting that smaller overall brain size, rather than specific regional effects, is related to prodromal mania symptoms. Lastly, longitudinal analyses revealed that brain volume at baseline did not predict prodromal mania symptoms at the second-year follow-up.

conclusionOur results support the structural differences observed in adults with bipolar disorder in prior work and refine our understanding of the neurostructural correlates of prodromal mania symptoms in children. These findings could enhance early identification and intervention efforts for youth at risk of developing bipolar disorder.

Indexed as

Bipolar DisorderBrainGray MatterManiaProdromal SymptomsChildFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMalebrain structurechildrengray matter volumemaniapathophysiology

Identifiers

PMID40977112
PMCPMC12451048

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.