ArticleAdvanced healthcare materials2026
Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration.
Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Engineering Hydrogels for Intrauterine Adhesion Therapy and Endometrial Regeneration.Gels (Basel, Switzerland) · 2026Review
- Recent advances in sex-specific reproductive microphysiological systems for the systematic evaluation of assisted reproductive technology.Materials today. Bio · 2026Review
- Spatiotemporal piezoelectric microspheres for wireless endometrial repair with improved pregnancy outcomes.Materials today. Bio · 2026Article
- Human Endometrial Extracellular Matrix Hydrogel Facilitated Endometrial Mesenchymal Stem Cells for Endometrial Regeneration.Advanced healthcare materials · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
The extracellular matrix (ECM) constantly remodels to tailor a temporal spatial specific environment for the residing cells to respond to physiological or pathological stimuli. Endometrial mesenchymal stem cells (eMSC) are excellent therapeutic candidates for treating endometrial problems. In-depth investigation of the native niche to understand the regulatory mechanisms of the stem cells will enable greater translational potentials in regenerating the thin or damaged endometrium. To understand the ECM niche of eMSC, endometrial ECM from full thickness human endometrial tissues at different menstrual phases are preserved by tissue decellularization and then transformed into hydrogel material (EndoGel). EndoGel exhibits excellent compatibility with eMSC by enhancing the expansion of eMSC in vitro and facilitating the therapeutic regenerative effect in vivo evidenced by the improved fertility outcome. Comparative study of the proliferative to secretory phase EndoGel reveals unique matrisome at specific phase of the human menstrual cycle. The post-regenerated endometrium shows distinct transcriptomic profile when transplanted with different menstrual phase EndoGel, suggesting the regulatory effect of the tissue matrix is menstrual phase specific. This is the first study comparing the endometrial matrix from specific human menstrual cycle and exploring its therapeutic potentials as a supportive biomaterial for eMSC to enhance endometrial regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.