Evidence map›Paper›PMID 40977105›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Control of Tetrazine Bioorthogonal Reactivity by Rotaxanation.

Carlos Fumero-Medina, Yaiza Pérez-Pérez, Lidia A Pérez-Márquez, Diego Álvarez de la Rosa, Teresa Giráldez, Nieves Rodríguez Paz, Jorge Pasán, Fernando Lahoz, David Tejedor, Jimena Scoccia and 1 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Control of Tetrazine Bioorthogonal Reactivity by Rotaxanation.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Carlos Fumero-MedinaInstituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), Avda. Astrofísico Fco. Sánchez 3, La Laguna, Tenerife, 38206, Spain.
Yaiza Pérez-PérezInstituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), Avda. Astrofísico Fco. Sánchez 3, La Laguna, Tenerife, 38206, Spain.
Lidia A Pérez-MárquezDepartamento de Ciencias Médicas Básicas-Fisiología, Facultad de Medicina, Instituto de Tecnologías Biomédicas, Universidad de La Laguna, La Laguna, Tenerife, 38200, Spain.ORCID https://orcid.org/0000-0001-5719-1491
Diego Álvarez de la RosaDepartamento de Ciencias Médicas Básicas-Fisiología, Facultad de Medicina, Instituto de Tecnologías Biomédicas, Universidad de La Laguna, La Laguna, Tenerife, 38200, Spain.ORCID https://orcid.org/0000-0002-4324-2793
Teresa GiráldezDepartamento de Ciencias Médicas Básicas-Fisiología, Facultad de Medicina, Instituto de Tecnologías Biomédicas, Universidad de La Laguna, La Laguna, Tenerife, 38200, Spain.ORCID https://orcid.org/0000-0002-4096-810X
Nieves Rodríguez PazInstituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), Avda. Astrofísico Fco. Sánchez 3, La Laguna, Tenerife, 38206, Spain.ORCID https://orcid.org/0000-0001-8133-6099
Jorge PasánMAT4LL, Departamento de Química, Unidad Departamental de Química Inorgánica, Universidad de La Laguna, La Laguna, Tenerife, 38206, Spain.ORCID https://orcid.org/0000-0001-9012-723X
Fernando LahozDepartamento de Física, IUdEA, Universidad de La Laguna, La Laguna, Tenerife, 38200, Spain.ORCID https://orcid.org/0000-0001-8008-1696
David TejedorInstituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), Avda. Astrofísico Fco. Sánchez 3, La Laguna, Tenerife, 38206, Spain.ORCID https://orcid.org/0000-0003-3262-0776
Jimena ScocciaInstituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), Avda. Astrofísico Fco. Sánchez 3, La Laguna, Tenerife, 38206, Spain.ORCID https://orcid.org/0000-0001-9296-3071
Romen CarrilloInstituto de Productos Naturales y Agrobiología (IPNA), Consejo Superior de Investigaciones Científicas (CSIC), Avda. Astrofísico Fco. Sánchez 3, La Laguna, Tenerife, 38206, Spain.ORCID https://orcid.org/0000-0002-7078-300X

Funding

Ministerio de Ciencia e Innovación PID2022-136566NB-I00
6 · The paper itself

Abstract

Rotaxanation is an efficient method to control the tetrazine-mediated inverse electron demand Diels-Alder (IEDDA) reaction. Tetrazine rotaxanes were synthesized in high yield by crown ether active template applied to the nucleophilic aromatic substitution of tetrazines. Kinetics of the bioorthogonal reaction with tetrazine rotaxanes were much slower than those with the corresponding threads. Interestingly, disassembly of the mechanical bond upon the application of the right stimulus activates IEDDA. Control of IEDDA in live cells was proved by means of a β-galactosidase sensitive tetrazine rotaxane: Enzymatic digestion allowed the Diels-Alder reaction, which resulted in a fluorescent compound.

Indexed as

Bioorthogonal chemistryIEDDARotaxaneSenescenceTetrazine

Identifiers

PMID40977105
PMCPMC12582004

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.