ArticleEuropean heart journal2026
Left bundle branch area pacing vs right ventricular pacing for atrioventricular block: the MELOS RELOADED study.
Article in European heart journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The flexibility of delayed fluoroscopic left ventricular angiography in periprocedural real-time visualization of the lead tip in left bundle branch pacing.Heart rhythm O2 · 2026Article
- Left bundle branch pacing in double-chambered left ventricle and perimembranous ventricular septal aneurysm: a case report.European heart journal. Case reports · 2026Article
- Cardiac implantable electronic devices in heart failure: needs, challenges, and real-world implementation.Heart failure reviews · 2026Review
- Conduction system pacing: what emerging evidence and what indications?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Review
- Characteristics of paced waveforms and current of injury prior to septal perforation during left bundle branch area pacing.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Takotsubo syndrome complicated by dynamic left ventricular outflow tract obstruction after left bundle branch area pacing.HeartRhythm case reports · 2026Article
- Permanent LEft ventricular septAl Pacing vs. right ventricular pacing in patients with atrioventricular conduction disorders-a randomized trial: rationale and design of the LEAP trial.European heart journal open · 2026Article
- Impact of Left Bundle Branch Area Pacing on Echocardiographic Parameters and Symptoms: Data From the Conduction System Pacing Italian Network Group (C-SING) Study.Journal of cardiovascular electrophysiology · 2026Observational
- Impact of Left Bundle Branch Pacing on Left Ventricular Mechanical Efficiency.Journal of cardiovascular electrophysiology · 2026Observational
- Left Bundle Branch Area Pacing versus Deep Septal Pacing in Patients After Transcatheter Aortic Valve Replacement.Journal of cardiovascular electrophysiology · 2026Article
- The Resynchronization Effect in Left Bundle Branch Pacing Can be Evaluated Non-Invasively With the Implementation of Lead V8.Journal of cardiovascular electrophysiology · 2026Article
- Conduction system pacing vs right ventricular pacing after TAVR: A systematic review and meta-analysis.Heart rhythm O2 · 2026Article
- Left bundle branch pacing optimized right ventricular resynchronization in a patient with severe right ventricular dilatation.HeartRhythm case reports · 2026Article
- Complete atrioventricular conduction system pacing in dextrocardia-a case report.European heart journal. Case reports · 2026Article
- Left Bundle Branch Area Pacing in Older Patients: A New Opportunity?Life (Basel, Switzerland) · 2026Review
- Conduction System Pacing Leads: Lumenless versus Stylet-driven Technologies in Contemporary Practice.Arrhythmia & electrophysiology review · 2026Review
- Adverse outcomes in patients with atrial fibrillation and a pacemaker: a cohort study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Article
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Authors and funding
23 authors.
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Abstract
BACKGROUND AND
aimsLeft bundle branch area pacing (LBBAP) promotes physiological synchronous activation of the left ventricle and may be particularly beneficial in patients with atrioventricular block (AVB), but its mortality benefit remains unclear. This study aims to compare long-term survival in AVB patients receiving either LBBAP or right ventricular pacing (RVP) and to analyse predictors of mortality during LBBAP.
methodsMELOS RELOADED, a multicentre European collaboration, was a registry-based study of pacemaker patients with AVB, left ventricular ejection fraction (LVEF) >40% and ventricular pacing >20%. The primary outcome was all-cause mortality based on national registries. A 1:1 propensity score matching was performed between the RVP and LBBAP groups. Kaplan-Meier curves and multivariable Cox proportional hazards models were used to estimate survival.
resultsIn total, 3382 patients receiving LBBAP or RVP were matched. At 4-year follow-up, the Kaplan-Meier curve showed an absolute difference in survival of 11.8% in favour of LBBAP (P < .001). LBBAP was a robust predictor of reduced mortality with a hazard ratio (HR) of 0.53 (95% confidence interval 0.42-0.65, P < .001). Within the LBBAP group, the following independent predictors of increased mortality were identified: lack of confirmed left bundle branch capture (HR 1.85, P < .001), lower percentage of ventricular pacing (HR 1.12), and age.
conclusionsThis is the first large study demonstrating the long-term survival benefit of LBBAP. This strengthens the use of LBBAP in AVB patients with preserved/mildly reduced LVEF while awaiting the results of randomized trials. Confirmation of left bundle branch capture seems advisable to achieve optimal results with LBBAP.
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