Evidence map›Paper›PMID 40977047›Full record

ArticleAmerican journal of epidemiology2025

Disaster-related home loss, mental health, and risk of cognitive disability: causal mediation analysis using longitudinal data of disaster survivors.

Sakurako S Okuzono, Koichiro Shiba, David T Zhu, Sarah Oh, Yu-Tien Hsu, Aki Yazawa, Hiroyuki Hikichi, Jun Aida, Katsunori Kondo, Henning Tiemeier and 1 more

Abstract read
In one paragraph

Article in American journal of epidemiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sakurako S OkuzonoDepartment of Social Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, United States.ORCID 0000-0003-2887-4415
Koichiro ShibaDepartment of Epidemiology, Boston University School of Public Health, 715 Albany st, Boston, MA, United States.ORCID 0000-0001-7956-6485
David T ZhuMedical Scientist Training Program, School of Medicine, Virginia Commonwealth University, 1201 E Marshall St, Richmond, VA 23298, United States.ORCID 0000-0002-0173-495X
Sarah OhDepartment of Social Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, United States.ORCID 0000-0001-5709-2311
Yu-Tien HsuDepartment of Social Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, United States.ORCID 0000-0001-6384-9878
Aki YazawaDepartment of Primary Care and Medical Education, Institute of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0002-4335-3880
Hiroyuki HikichiDivision of Public Health, Kitasato University School of Medicine, 1-15-1 Kitazato, Minami, Sagamihara, Kanagawa 252-0374, Japan.ORCID 0000-0002-7791-464X
Jun AidaTokyo Dental and Medical University, 1-5-45, Yushima, Bunkyo-ku, Tokyo, Japan.ORCID 0000-0002-8405-9872
Katsunori KondoChiba University, 1-33 Yayoicho, Inage Ward, Chiba, Japan.
Henning TiemeierDepartment of Social Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, United States.ORCID 0000-0002-4395-1397
Ichiro KawachiDepartment of Social Behavioral Sciences, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, United States.

Funding

Impact of social cohesion on functional recovery after earthquake and tsunamiR01AG042463 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI KAWACHI, ICHIRO · 2013 to 2022
$4.9M
Grants-in Aid for Scientific Research from the Japan Society for the Promotion of Science KAKENHI 22390400, KAKENHI 20H00557, and KAKENHI 24390469Health Labour Sciences Research Grant from the Japanese Ministry of Health, Labour, and Welfare H24-Choju-Wakate-009Japan Agency for Medical Research and Development (AMED) JP17dk0110017, JP18dk0110027, JP18ls0110002, JP18le0110009, JP19dk0110034, JP19dk0110037, JP20dk0110034NIA NIH HHS R01 AG042463NIH HHS R01 AG042463Strategic Research Foundation Grant-Aided Project for Private Universities from the Japanese Ministry of Education, Culture, Sports, Science, and Technology Grant S0991035
6 · The paper itself

Abstract

Emerging evidence links disaster-related home loss to increased cognitive impairment, yet the mechanisms underlying this association remain unclear. This study examines whether psychopathology and diminished social connection mediate the relationship between home loss and cognitive disability among older disaster survivors. We conducted a prospective cohort study of survivors of the 2011 Great East Japan Earthquake and Tsunami. Causal mediation analysis was used to estimate the role of post-disaster depressive symptoms, posttraumatic stress symptoms, social support, social participation, and social cohesion in mediating the association. Analyses adjusted for pre-disaster confounders. Among 3138 survivors, 140 experienced disaster-related home loss, and 498 experienced mild to severe cognitive disability. Home loss was associated with increased cognitive impairment, increased psychopathology, as well as decreased social connections. Forty-eight percent of the total effect of home loss on cognitive impairment was mediated by depressive symptoms, but not posttraumatic stress symptoms. Although the effect was marginal, 19% was also explained by a decline in social cohesion. Disaster-related home loss was associated with subsequent cognitive impairment through post-disaster depressive symptoms and decline in social cohesion. Group relocation and early intervention for those with depressive symptoms might ameliorate the adverse effects of home loss in cognitive disability.

Indexed as

Cognitive DysfunctionDisastersEarthquakesMental HealthSurvivorsAgedAged, 80 and overDepressionFemaleHumansJapanLongitudinal StudiesMaleMediation AnalysisMiddle AgedProspective StudiescognitiondepressiondisastermediationPTSDtrauma

Identifiers

PMID40977047
PMCPMC12671964

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.