Chronic Intermittent Ethanol and Withdrawal Suppress Evoked and Spontaneous GABA Release Onto Distinct Populations of Basolateral Amygdala Principal Neurons.
Michaela E Price, Hailey X Egido-Betancourt, Sarah E Sizer, Brian P Parrish, Nancy J Alexander, Kimberly F Raab-Graham, Brian A McCool
Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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5 · Who and what money
Authors and funding
7 authors.
Michaela E PriceDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Hailey X Egido-BetancourtDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Sarah E SizerDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Brian P ParrishDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Nancy J AlexanderDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Kimberly F Raab-GrahamDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Brian A McCoolDepartment of Translational Neuroscience, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-1002-9435
Funding
Wake Forest Translational Alcohol Research Center (WF-TARC)P50AA026117 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Jeffrey L. Weiner · 2018 to 2026
$16.2M
MULTI-DISCIPLINARY TRAINING IN THE BIOLOGY OF ALCOHOLISMT32AA007565 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BRIAN A MCCOOL · 1994 to 2026
$10.1M
The Ethanol - Anxiety Interaction: Cellular MechanismsR01AA014445 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCCOOL, BRIAN A · 2004 to 2023
$5.2M
Biochemical Studies Underlying Acute Ethanol's Antidepressant-like effects during Withdrawal in a Preclinical Model of Ethanol DependenceR01AA029691 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Kimberly Frances Raab-Graham · 2023 to 2026
$1.4M
Investigating How Alcohol Withdrawal Dysregulates 'Reward' and 'Aversion' Neurons in the Basolateral AmygdalaF31AA029933 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI PRICE, MICHAELA · 2022 to 2023
$93k
Dissecting the Role of Nucleus Basalis Magnocellularis Circuitry in Basolateral Amygdala Physiology and Regulation of Anxiety Following Chronic Ethanol Exposure and WithdrawalF31AA028722 · NIAAA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SIZER, SARAH ELIZABETH · 2021 to 2022
Unique populations of basolateral amygdala (BLA) neurons regulate anxiety and reward through projections targeting downstream regions like the bed nucleus of the stria terminalis (BNST) and nucleus accumbens (NAC). We showed previously that withdrawal from chronic ethanol exposure (CIE/WD) produced population- and sex-specific alterations to distinct glutamatergic inputs. The current study examined GABAergic function in these distinct populations (BLA
Indexed as
Basolateral Nuclear ComplexCentral Nervous System DepressantsEthanolgamma-Aminobutyric AcidNeuronsSubstance Withdrawal SyndromeAnimalsFemaleInterneuronsMaleNucleus AccumbensParvalbuminsRatsReceptors, Opioid, muSex FactorsVesicular Inhibitory Amino Acid Transport ProteinsCentral Nervous System DepressantsEthanolgamma-Aminobutyric AcidParvalbuminsReceptors, Opioid, muVesicular Inhibitory Amino Acid Transport Proteinsfeed‐back inhibitionfeed‐forward inhibitionopioid receptorswhole‐cell voltage‐clamp electrophysiology
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Chronic Intermittent Ethanol and Withdrawal Suppress Evoked and Spontaneous GABA Release Onto Distinct Populations of Basolateral Amygdala Principal Neurons. · full record | OpenQuestion