SynthesisBrain and behavior2025
A Meta-Analysis of Multidimensional Cognitive Functions Changes in Different Intensities of High-Altitude Hypoxia.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Meta-Analysis of Multidimensional Cognitive Functions Changes in Different Intensities of High-Altitude Hypoxia.Brain and behavior · 2025Pooled it
- Hyperbaric oxygen intervention enhances cooperative gains in high-trust people at high altitude: the role of medial prefrontal interbrain synchrony.Social cognitive and affective neuroscience · 2026Trial
- Chronic high-altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular-immune-neuronal network.Neuroprotection (Chichester, England) · 2026Review
- Personality-Related Traits and Psychological and Cognitive Outcomes Under High-Altitude Hypoxia: A Trait-Process-Outcome Framework.Behavioral sciences (Basel, Switzerland) · 2026Review
- Dynamic functional connectivity variability may explain hypoxia-induced cognitive impairment at high-altitude.iScience · 2026Article
- Cardiovascular Exercise Physiology Under Hypoxia, Microgravity, and Heat Stress: A Review with Public Health Implications.International journal of environmental research and public health · 2026Review
- Article
- Tetramethylpyrazine exerts neuroprotective effects in a mouse model of acute hypobaric hypoxia.Frontiers in pharmacology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis meta-analysis aims to comprehensively evaluate the impact of high-altitude hypoxia on multidimensional cognitive functions, considering moderating variables such as altitude, exposure time, cognitive domain, and experimental design.
methodsA three-level meta-analysis was conducted on 59 studies (1966-2024) comprising 739 effect sizes. Studies were screened and coded according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Cognitive tasks were categorized into seven domains: executive control, working memory, long-term memory, perceptual ability, psychomotor skill, attention, and others. Hedges' g was used as the effect size measure, and multilevel modeling was applied to account for dependent effect sizes.
findingsHigh-altitude hypoxia significantly impaired overall cognitive function (g = -0.424, p < 0.001). Long-term memory and perceptual functions were most affected, followed by executive control, attention, and psychomotor skills; working memory was least impacted. Cognitive impairment was significant at altitudes above 2500 m. Acute (< 3 days) and chronic (> 30 days) exposure significantly affected cognition, while intermediate exposures (3-30 days) did not. Subgroup analyses revealed varying sensitivity across cognitive domains to altitude and exposure duration.
conclusionHigh-altitude hypoxia adversely affects cognitive function, with severity varying by cognitive domain, altitude, and exposure duration. These findings highlight the need for tailored interventions and further research into acclimatization and de-acclimatization processes.
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