ArticleHLA2025
Memory B-Cell Assay Uncovers Prior HLA Sensitisation in Transplant Candidates With Prior Exposure to Non-Self HLA.
Article in HLA, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Reversing pregnancy-induced B cell sensitization to facilitate the induction of transplant tolerance in postpartum recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Profiling Allogeneic HLA-specific B-cell Responses Utilizing a 64-plex Single-HLA Reporter Cell Panel.bioRxiv : the preprint server for biology · 2026Article
- Pregnancy-shaped donor-directed alloimmune recall in husband-to-wife kidney transplantation: an integrative mechanistic framework.Frontiers in immunology · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Memory B cells are critical in kidney transplantation for rapid anti-HLA antibody production upon re-exposure, yet pretransplant serum antibodies often remain undetectable despite prior sensitisation. Using R848 stimulation (a TLR7/8 agonist inducing polyclonal B-cell activation), we tested 45 kidney recipients with past sensitisation events but no circulating antibodies. The assay identified 56 memory B-cell-derived HLA antibodies (HLAm) in 8 patients, primarily from pregnancy or transfusion sensitisation, with a 17-year average latency between exposure and transplantation. This pilot demonstrates that latent memory B cells may reactivate post-transplant, driving antibody production and adverse outcomes. Our findings advocate integrating memory B-cell assays into pretransplant risk assessment to improve sensitivity in detecting subclinical HLA sensitisation, refining donor-recipient matching strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.