ArticleJournal of veterinary internal medicine
Applicability of Global Hemostatic Tools for Evaluation of Hemostatic State and Detection of Thrombosis in Cats With Cardiomyopathies.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Early activation of Virchow's triad in feline hypertrophic cardiomyopathy: beyond spontaneous echo contrast and insights into translational thromboembolism.Frontiers in veterinary science · 2026Review
- Applicability of Global Hemostatic Tools for Evaluation of Hemostatic State and Detection of Thrombosis in Cats With Cardiomyopathies.Journal of veterinary internal medicineArticle
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Authors and funding
11 authors.
Funding
Abstract
backgroundArterial thromboembolism (ATE) is a known complication of cardiomyopathies (CM) in cats. Hypercoagulability is believed to be one predisposing factor.
objectiveAssess applicability of global hemostatic tests for evaluating the systemic hemostatic state in cats with CM with concurrent ATE (CM + ATE). ANIMALS: Six cats with CM + ATE, 11 cats with CM, and 13 healthy cats.
methodsProspective case-control study (2016-2020). Echocardiography, whole blood thromboelastography (TEG), and thrombin generation testing (TGT) were performed. Hypercoagulability was defined for TEG as shortened reaction time (R), shortened kinetics (K), increased angle, or increased maximal amplitude and for TGT as decreased lag time, decreased time to peak, increased peak, or increased endogenous thrombin potential (ETP). If ≥ 1 parameter showed significant hypercoagulability compared with healthy cats, and no parameter showed significant hypocoagulability, the patient was considered hypercoagulable. The opposite criteria defined hypocoagulability.
resultsHypocoagulability was detected for cats with CM + ATE compared with both cats with CM and healthy cats, characterized by significantly prolonged R and K on TEG as well as significantly increased time-to-peak and decreased peak and ETP on TGT. Additionally, some thrombocytopenia was considered likely in cats with CM + ATE, but could not be fully evaluated because of a high prevalence of concurrent platelet aggregation. CONCLUSIONS AND CLINICAL IMPORTANCE: A systemic hypocoagulable state was detected in cats with CM with concurrent ATE. Similar hemostatic paradoxes in human patients with thrombosis have been suggested to be related to platelet exhaustion, local endocardial hypercoagulability, or alterations in regulatory proteins.
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