ArticleBMC plant biology2025
Widely targeted metabolic profiling reveals drought resistance mechanisms in alfalfa leaves.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Untargeted Metabolomics of Xylem Sap Exudates in Two Common Bean Genotypes with Contrasting Growth Rates Under Water Deficit During Pod Filling.Metabolites · 2026Article
- Cold Plasma Treatment Enhances Drought Tolerance of Alfalfa (Antioxidants (Basel, Switzerland) · 2026Article
- Construction of Drought-Resistant Microbial Consortium and Effect on Alfalfa Growth Under Drought Stress.Plants (Basel, Switzerland) · 2026Article
- Spatial Heterogeneity of Metabolic Response to Drought Stress inMetabolites · 2026Article
- Advances in Potassium Silicate-Induced Drought Tolerance in Tropical Tree Seedlings: Effects on Morphological Traits, Physiological Responses, and Biochemical Regulation.Plants (Basel, Switzerland) · 2025Article
- Genotype-Dependent Phenylpropanoid Pathway Specialization in Prunus avium Fruits and Leaves Revealed by Untargeted Metabolomics.Physiologia plantarumArticle
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Abstract
Drought is considered a primary factor constraining alfalfa (Medicago sativa L.) yield and acreage. To understand the internal drought resistance mechanisms of alfalfa is essential for breeding drought-resistant alfalfa varieties. Here, we compared the phenotypic characteristics, metabolic pathways and metabolites of drought-resistant (Longzhong, LZ) and drought-sensitive (Gannong No. 3, G3) varieties under drought stress. Phenotypic analysis revealed that drought stress reduced plant height, single plant fresh weight, single plant dry weight and leaf RWC in alfalfa, with a greater effect observed in G3. The root length of LZ increased under drought stress, whereas there was no significant change in the root length of G3. Widely targeted metabolomics revealed that LZ could maintain higher glycolysis/gluconeogenesis and tricarboxylic acid cycle under drought stress, which provided more ATP and substrates for amino acids biosynthesis, arginine and proline metabolism and phenylpropanoid metabolism. This allowed LZ to accumulate more amino acids, spermidine, spermine, 4-aminobutyric acid, naringenin, isoliquiritigenin, glycitein, glycitin, calycosin, ferulate, scopoline, scopoletin, sinapyl alcohol and coniferin, which favor the enhancement of drought resistance in alfalfa. Moreover, widely targeted metabolomics showed salicylic acid and trans-zeatin were key hormones involved in drought resistance in alfalfa. The results of this study provide useful insights into the enhancement of drought resistance in alfalfa through metabolic regulatory mechanisms, which provides a theoretical basis for the breeding drought-resistant alfalfa varieties.
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