Evidence map›Paper›PMID 40976814›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2025

Experimental Study: Youth vs. Life Experience of Adulthood in Terms of Acute Stress Response.

M V Kondashevskaya, V V Aleksankina, K A Artem'eva, A I Anurkina, K A Kasabov, D A Areshidze, L M Mikhaleva

Abstract read
PubMed Publisher
In one paragraph

Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

M V KondashevskayaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia. marivladiko@mail.ru.
V V AleksankinaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
K A Artem'evaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
A I AnurkinaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
K A KasabovAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
D A AreshidzeAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
L M MikhalevaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age differences in the response to acute stress were studied in young and mature reproductive-age inbred male Wistar rats. Stress was found to increase the corticosterone level in both age groups, while the testosterone level decreased and the leptin concentration increases. In response to stress, young rats showed a classic decrease in the mass coefficients (MCs) of the thymus and liver and an increase in the MCs of the adrenal glands and heart. In contrast, mature rats showed a decrease in the MC of the adrenal glands and stability of the MC of other visceral organs under all experimental conditions. The rats were tested in the elevated plus maze (EPM), and opposite behavioral changes were observed in the two groups after stress exposure. Exploratory activity decreased in the young rats and increased in the mature rats. It was assumed that neurons of the dorsal part of the periaqueductal grey and the cerebellum were in an excited state as a result of accumulated life experience in the mature rats and that this was expressed as more intense locomotor activity (LA) and a higher efficiency of decision-making mechanisms in choosing the direction of movement in the EPM. Lack of such experience in the young rats inhibited the LA speed and decision-making mechanisms, inducing a feeling of uncertainty during navigation in the EPM. The data can have a wide range of applications in preclinical studies related to health, aging, stress, and modeling of various diseases.

Indexed as

AgingStress, PsychologicalAdrenal GlandsAnimalsBehavior, AnimalCorticosteroneLeptinMaleRatsRats, WistarTestosteroneCorticosteroneLeptinTestosteroneacute stressbehaviorelevated plus mazehormonesinbred Wistar ratsyoung and mature reproductive age

Identifiers

PMID40976814

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.