Evidence map›Paper›PMID 40976809›Full record

ArticleInternational journal of hematology2025

Langerhans cell histiocytosis with mesenteric involvement successfully treated with trametinib: a rare cause of small intestine obstruction.

Long Chang, Kai-Ni Shen, Ya-Ping Luo, Xin-Xin Cao

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In one paragraph

Article in International journal of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Long Chang *Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Kai-Ni Shen *Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Ya-Ping LuoState Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Beijing, People's Republic of China.
Xin-Xin CaoDepartment of Medical Oncology, National Cancer Center, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China. caoxinxin@126.com.ORCID http://orcid.org/0000-0001-7884-3073

Funding

Beijing Natural Science Haidian frontier Foundation L222081National Natural Science Foundation of China Grant No. 82370179
6 · The paper itself

Abstract

Langerhans cell histiocytosis (LCH) is a rare type of histiocytosis with various clinical manifestations. The differential diagnosis for an infiltrative process in the mesentery includes histiocytosis, such as Erdheim-Chester disease (ECD) and Rosai-Dorfman disease (RDD), but mesenteric involvement has never been reported. Here we present the first documented case of LCH. A 24-year-old man presented with diabetes insipidus and was diagnosed with LCH via mesenteric biopsy, which demonstrated mesenteric involvement and the BRAF

Indexed as

Histiocytosis, Langerhans-CellIntestine, SmallMesenteryPyridonesPyrimidinonesHumansMaleMutationPositron Emission Tomography Computed TomographyProto-Oncogene Proteins B-rafTreatment OutcomeYoung AdultBRAF protein, humanProto-Oncogene Proteins B-rafPyridonesPyrimidinonestrametinibLangerhans cell histiocytosisMesenteric involvementTarget therapy

Identifiers

PMID40976809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.