Evidence map›Paper›PMID 40976669›Full record

ArticleBMJ open2025

Protocol for development of SPIRIT and CONSORT extensions for reporting climate and environmental outcomes in randomised trials (SPIRIT-ICE and CONSORT-ICE).

Johanne Juul Petersen, Linn Hemberg, Lehana Thabane, Sally Hopewell, An-Wen Chan, Asbjørn Hróbjartsson, Ole Mathiesen, Sujane Kandasamy, Nandi Siegfried, Paula R Williamson and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Balancing carbon reduction and treatment adequacy in sustainable continuous renal replacement therapy.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Johanne Juul PetersenRigshospitalet Copenhagen Trial Unit, Copenhagen, Denmark johanne.juul.petersen@ctu.dk.ORCID http://orcid.org/0000-0001-9837-1958
Linn HembergDepartment of Clinical Sciences, Lund University, Lund, Sweden.
Lehana ThabaneDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-0355-9734
Sally HopewellNuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6881-6984
An-Wen ChanDepartment of Medicine, Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
Asbjørn HróbjartssonOpen Patient Data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
Ole MathiesenDepartment of Anaesthesia, Zealand University Hospital, Køge, Denmark.
Sujane KandasamyDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0003-4326-2783
Nandi SiegfriedMental Health, Alcohol, Substance Use and Tobacco Research Unit, South African Medical Research Council, Cape Town, South Africa.
Paula R WilliamsonMRC-NIHR Trials Methodology Research Partnership, Department of Health Data Science, University of Liverpool, Liverpool, UK.ORCID http://orcid.org/0000-0001-9802-6636
Lisa FoxClinical Trials and Statistics Unit, The Institute of Cancer Research, London, UK.
Caroline Barkholt KampRigshospitalet Copenhagen Trial Unit, Copenhagen, Denmark.
Jean-Marc HoffmannClinical Trials Center, University Hospital Zurich, Zürich, Switzerland.
Stig BrorsonCentre for Evidence-Based Orthopedics, Zealand University Hospital, Koge, Denmark.ORCID http://orcid.org/0000-0001-5337-758X
Isabelle BoutronCentre for Research in Epidemiology and Statistics (CRESS), Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Paris-Sorbonne University, Paris, France.
Forbes McGainDepartment of Critical Care, The University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, Australia.
Scott McAlisterCentre for Health Policy, The University of Melbourne Faculty of Medicine Dentistry and Health Sciences, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-8702-6374
Lilian MutenguAfrican Academy of Sciences, Nairobi, Kenya.
Jonathan SlutzmanCenter for the Environment and Health, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-2559-8905
Jodi D ShermanDepartment of Anesthesiology, Yale School of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Peter Bentzer *Department of Clinical Sciences, Lund University, Lund, Sweden.
Janus C Jakobsen *Rigshospitalet Copenhagen Trial Unit, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe WHO has declared climate change the defining public health challenge of the 21st century. Incorporating climate and environmental outcomes in randomised trials is essential for enhancing healthcare treatments' sustainability and safeguarding global health. To implement such outcomes, it is necessary to establish a framework for unbiased and transparent planning and reporting. We aim to develop extensions to the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT 2025) and Consolidated Standards of Reporting Trials (CONSORT 2025) statements by introducing guidelines for reporting climate and environmental outcomes. METHODS AND ANALYSIS: This is a protocol for SPIRIT and CONSORT extensions on reporting climate and environmental outcomes in randomised trials termed SPIRIT-Implementing Climate and Environmental (ICE) and CONSORT-ICE. The development of the extensions will consist of five phases: phase 1-project launch, phase 2-review of the literature, phase 3-Delphi survey, phase 4-consensus meeting and phase 5-dissemination and implementation. The phases are expected to overlap. The SPIRIT-ICE and CONSORT-ICE extensions will be developed in parallel. The extensions will guide researchers on how and what to report when assessing climate and environmental outcomes. ETHICS AND DISSEMINATION: The protocol was submitted to the Danish Research Ethics Committees, Denmark in June 2025. Ethics approval is expected in September 2025. The SPIRIT and CONSORT extensions will be published in international peer-reviewed journals.

Indexed as

Climate ChangeRandomized Controlled Trials as TopicResearch DesignResearch ReportDelphi TechniqueGuidelines as TopicHumansClimate ChangePUBLIC HEALTHSTATISTICS & RESEARCH METHODS

Identifiers

PMID40976669
PMCPMC12458820

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.