ArticleJournal of cardiac failure2026
Antibody-independent Microvascular Inflammation Impacts Long-term Risk in Heart Transplantation.
Article in Journal of cardiac failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics.Nature cardiovascular research · 2026Article
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9 authors.
Funding
Abstract
backgroundMicrovascular inflammation (MVI) after heart transplantation (HT) can occur with or without circulating anti-human leukocyte antigen donor-specific antibodies (DSAs). We sought to characterize the relationship between MVI, with or without accompanying DSA, and post-transplant outcomes. METHODS AND
resultsWe analyzed 8305 endomyocardial biopsies from 832 adult and pediatric HT recipients between July 1, 2013, and October 31, 2023. Endomyocardial biopsies were graded by consensus guidelines, with MVI defined as histological evidence of AMR grade ≥1. Rejection phenotypes were classified as no rejection, isolated cellular rejection, DSA-negative MVI, and DSA-positive MVI. Cox models with time-varying covariates were constructed to evaluate associations with incident cardiac allograft vasculopathy (CAV) and mortality, adjusting for donor and recipient age. Among 832 HT recipients, 238 developed CAV and 121 died over a median follow-up of 4 years (interquartile range 2.3-6.4 years). Compared with individuals who never experienced biopsy-proven rejection, DSA-negative MVI was independently associated with CAV (hazard ratio [HR] 1.47, 95% confidence interval [CI] 1.00-2.16, P = 0.047). DSA-positive MVI was associated with mortality (HR 1.97, 95% CI 1.07-3.64) with DSA-negative MVI demonstrating directional concordance (HR 1.50, 95% CI 0.87-2.57), independent of CAV (HR 1.71, 95% CI 1.13-2.58). These associations remained consistent when stratified by adult and pediatric subgroups and in a 6-month landmark sensitivity analysis.
conclusionsMVI, with or without DSA, may be harmful in HT, extending recent renal findings to thoracic transplantation. Understanding the mechanistic basis for these results will be essential for identifying novel targets for therapeutic modulation and prolonging graft survival.
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