Evidence map›Paper›PMID 40976492›Full record

ArticleNeuroImage2025

Measuring the potential risk of re-identification of imaging research participants from open-source automated face recognition software.

Carl M Prakaashana, Marios Savvides, Jeffrey L Gunter, Matthew L Senjem, Prashanthi Vemuri, Kejal Kantarci, Johnanthan Graff-Radford, Ronald C Petersen, Clifford R Jack, Christopher G Schwarz

Abstract read
In one paragraph

Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carl M PrakaashanaDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Marios SavvidesCarnegie Mellon University, Pittsburgh, PA, USA.
Jeffrey L GunterDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Matthew L SenjemDepartment of Radiology, Mayo Clinic, Rochester, MN, USA; Department of Information Technology, Mayo Clinic, Rochester, MN, USA.
Prashanthi VemuriDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Johnanthan Graff-RadfordDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN, USA.
Christopher G SchwarzDepartment of Radiology, Mayo Clinic, Rochester, MN, USA. Electronic address: schwarz.christopher@mayo.edu.

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
Rochester Epidemiology ProjectR01AG034676 · NIA · MAYO CLINIC ROCHESTER · PI ROCCA, WALTER A, ST SAUVER, JENNIFER LYNN · 2010 to 2019
$9.5M
Investigating Resistance and Resilience Mechanisms in Alzheimer’s DiseaseR01AG056366 · NIA · MAYO CLINIC ROCHESTER · PI PRASHANTHI VEMURI · 2017 to 2026
$7.0M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Premenopausal bilateral oophorectomy and biomarkers of Alzheimer’s and cerebrovascular diseasesR01AG093767 · NIA · MAYO CLINIC ROCHESTER · PI KEJAL KANTARCI, WALTER A ROCCA · 2025 to 2026
$3.5M
Protecting the Confidentiality of Participants in Studies of Alzheimer's Disease and Related Dementias by Replacing Face Imagery in MRIR01AG068206 · NIA · MAYO CLINIC ROCHESTER · PI SCHWARZ, CHRISTOPHER GEORGE · 2021 to 2024
$3.2M
Development, Validation, and Application of an Imaging based CVD ScaleR01NS097495 · NINDS · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 2016 to 2020
$2.9M
Protecting the Confidentiality of Participants in Studies of Alzheimer's Disease and Related Dementias by Replacing Face Imagery in MRIR56AG068206 · NIA · MAYO CLINIC ROCHESTER · PI SCHWARZ, CHRISTOPHER GEORGE · 2020 to 2020
$793k
NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG056366NIA NIH HHS R01 AG068206NIA NIH HHS R01 AG093767NIA NIH HHS R37 AG011378NIA NIH HHS R56 AG068206NIA NIH HHS U01 AG006786NINDS NIH HHS R01 NS097495NINDS NIH HHS U01 NS100620
6 · The paper itself

Abstract

In recent years facial recognition software has gone from an area of research to widespread adoption and broad public availability. Open-source face recognition packages are freely available on the internet for anyone to download, and several public websites allow users to run facial recognition on photos without needing any technical knowledge or equipment beyond internet access, making facial recognition accessible for anyone to use for any purpose. Previous research has demonstrated the ability of commercial software to identify a person based on facial content in brain imaging. In this study we tested two commercial facial recognition programs and a variety of popular open-source computer vision and facial recognition software packages to measure how accurately they could be used for reidentification of research participants in brain imaging studies. We tested a "population to sample" threat model, measuring the rates of success for which face recognition software selected the correct MRI-based face reconstruction from a set of 182 participants as its top-scoring match for input facial photographs. We found that the freely available open-source software packages we tested can reidentify a research participant with up to 59 % accuracy. This was less than the commercial packages, which were able to achieve much higher accuracies in the ranges of 92 % and 98 % in identical testing scenarios, but it demonstrates the feasibility of re-identifying faces in research MRI even by individuals with access to only freely available software. As the trust and confidence of potential participants is essential to brain imaging research, especially with widespread and mandated data-sharing of brain scans, this further supports the need to replace identifiable face imagery in brain images to protect the privacy of research participants.

Indexed as

Automated Facial RecognitionFacial RecognitionImage Processing, Computer-AssistedSoftwareAdultFaceFemaleHumansMagnetic Resonance ImagingMaleYoung AdultData sharingDe-facingDe-identificationFace recognition

Identifiers

PMID40976492
PMCPMC12560120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.