ArticleJournal of adolescence2026
Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.
Article in Journal of adolescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- More Than Hurt Feelings: Associations Between Perceived Racial Discrimination and Mental Health, Substance Use, and Victimization Among Racial and Ethnic Minority Adolescents.Journal of racial and ethnic health disparities · 2026Article
- Biomarkers and Breakdowns: Neuroinflammatory Drivers Linking Sleep Disorders and Chronic Pain.Biomedicines · 2026Review
- Genetic and Environmental Associations Among Pain, Sleep Disturbances, and Substance Use Intent in Early Adolescence.Journal of adolescence · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposePain, sleep disturbances, and substance use are common in adolescence, with research indicating that genetic and environmental factors account for variation in each of these behavioral and health outcomes. Moreover, pain, sleep disturbances, and substance use often co-occur during adolescence. However, research has not examined whether there is genetic and/or environmental covariation across these constructs in early adolescence or in diverse samples. To address these gaps, we examined genetic and environmental covariation in pain, sleep disturbances, and substance use intent in early adolescence.
methodsOur study used data from the Adolescent Brain Cognitive Development (ABCD) twin subsample at age 12/13 (834 monozygotic twins (MZ) and 1262 dizygotic (DZ) twins; 50% female; 64% White, 14% African American, 12% Latinx/Hispanic, 10% multiracial/other). We estimated univariate twin ACE decompositions for the number of pain sites, sleep disturbances, and intent to use substances as well as pairwise bivariate Cholesky decompositions across phenotypes.
resultsWe found variation in pain attributable to additive genetic and unique environmental influences. Variation in sleep disturbances was due to additive genetic, unique environmental, and shared environmental influences. Variation in substance use intent was due to additive genetic and unique environmental influences. There was some evidence of shared genetic etiology across pain and sleep, and some evidence of shared environmental etiology across pain and substance use intent. DISCUSSION: Findings highlight the importance of examining shared genetic and environmental etiology underlying pain, sleep, and substance use in early adolescence, which can help identify transdiagnostic targets for early prevention and interventions of health issues.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.