Evidence map›Paper›PMID 40975735›Full record

ArticleAnnals of surgical oncology2025

Does Intraoperative Radiation Therapy Provide Comparable Local Control to Partial Breast Irradiation in Patients Suitable for Omission of RT?

Anirudh Bommireddy, Arya Patel, Sean Parker, Ahmed Halima, Elizabeth Obi, Connor Spera, Zahraa AlHilli, Anna Chichura, Sheen Cherian, Rahul D Tendulkar and 1 more

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Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anirudh BommireddyDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Arya PatelDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Sean ParkerDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Ahmed HalimaDepartment of Radiation Oncology, Geisinger Medical Center, Danville, PA, USA.
Elizabeth ObiDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Connor SperaDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Zahraa AlHilliBreast Center, Integrated Surgical Institute, Cleveland Clinic, Cleveland, OH, USA.
Anna ChichuraBreast Center, Integrated Surgical Institute, Cleveland Clinic, Cleveland, OH, USA.
Sheen CherianDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Rahul D TendulkarDepartment of Radiation Oncology, Cleveland Clinic, Cleveland, OH, USA.
Chirag ShahDepartment of Radiation Oncology, Allegheny Health Network, Pittsburgh, PA, USA. Chirag.Shah@ahn.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPartial breast irradiation (PBI) offers the ability for smaller treatment volumes, reduced toxicities, and shorter treatment duration. One alternative to PBI is intraoperative radiation (IORT), though local control outcomes are mixed. The purpose of this analysis is to compare outcomes with PBI and IORT, including in those patients suitable for omission of radiation therapy. PATIENTS AND

methodsPatients with early stage breast cancer who received PBI or IORT between 2011 and 2021 were evaluated. PBI patients received 30 Gy in 5 fractions and IORT patients received 20 Gy in 1 fraction using a 50 kv device. Patients with less than 2 years of follow-up were excluded from the analysis.

resultsA total of 245 patients with a median age of 67 years received PBI, and 202 patients with a median age of 70 years received IORT. Median follow-up was 3.5 years for PBI and 6.5 years for IORT; 5-year local control (LC) was 99.6% for PBI versus 94.7% for IORT (p = 0.01). For patients meeting PRIME II criteria, 5-year LC was 99.2% for PBI versus 94.1% for IORT (p = 0.09), while for patients meeting CALGB 9343 criteria, 5-year LC was 100% for PBI versus 94.8% for IORT (p = 0.11).

conclusionsIORT has worse local control as compared with 5-fraction PBI, even among patients eligible for omission of RT. Given concerns regarding compliance with endocrine therapy, for patients eligible for omission of RT, 5 fraction PBI offers a convenient treatment option to optimize local control, while IORT has a limited role as monotherapy, consistent with current guidelines.

Indexed as

Breast cancerIntraoperative radiation therapyLocoregional therapyPartial breast irradiationRadiation therapy

Identifiers

PMID40975735

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