ArticleKidney international2025
Where next for potassium binders in hemodialysis?
Article in Kidney international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
Abstract
Patients on hemodialysis frequently experience hyperkalemia, a condition linked to arrhythmia and mortality. The DIALIZE-Outcomes trial was designed to investigate whether the oral potassium binder, sodium zirconium cyclosilicate, could reduce cardiovascular events. The trial was terminated early because of low event accrual and high rates of medication discontinuation. From the available data, no difference in outcomes was observed, despite better potassium control. We discuss the strengths and limitations of the trial and highlight considerations for future studies.
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Registered trials
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