Evidence map›Paper›PMID 40975489›Full record

ArticleMetabolism: clinical and experimental2026

Enhancing cardiac serine biosynthesis mitigates the progression of dilated cardiomyopathy in mice.

Maryam Kay, Anne-Maj Samuelsson, Nike Bharucha, Xueyi Li, Rohin Ramchandani, Rachel E Baum, Diego Ruiz Arvizo, Aurélie Laguerre, Sherin Lajevardi, Shrikaar Kambhampati and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolism: clinical and experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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  3. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maryam KayDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Anne-Maj SamuelssonCardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA.
Nike BharuchaDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Xueyi LiCardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA.
Rohin RamchandaniDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Rachel E BaumDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Diego Ruiz ArvizoDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Aurélie LaguerreSalk Institute for Biological Studies, La Jolla, CA, USA.
Sherin LajevardiDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA.
Shrikaar KambhampatiSalk Institute for Biological Studies, La Jolla, CA, USA.
Christian M MetalloSalk Institute for Biological Studies, La Jolla, CA, USA.
Michael S KapiloffCardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA.
Ioannis KarakikesDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA, USA; Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: ioannis1@stanford.edu.

Funding

Unraveling the pathogenesis of familial dilated cardiomyopathy towards precision medicineR01HL139679 · NHLBI · STANFORD UNIVERSITY · PI Ioannis Karakikes · 2018 to 2026
$4.2M
The Role of 3-Dimensional Genome Integrity In Cardiac LaminopathiesR01HL150414 · NHLBI · STANFORD UNIVERSITY · PI KARAKIKES, IOANNIS · 2020 to 2023
$2.1M
Calcineurin compartmentation and regulation of pathological cardiac remodelingR01HL158052 · NHLBI · STANFORD UNIVERSITY · PI KAPILOFF, MICHAEL SETH · 2021 to 2024
$2.1M
Investigating the role of the Unfolded Protein Response in Genetic Dilated CardiomyopathyF32HL167558 · NHLBI · STANFORD UNIVERSITY · PI BAUM, RACHEL · 2024 to 2025
$112k
American Heart Association 25POST1379432NHLBI NIH HHS F32 HL167558NHLBI NIH HHS R01 HL139679NHLBI NIH HHS R01 HL150414NHLBI NIH HHS R01 HL158052
6 · The paper itself

Abstract

Genetic dilated cardiomyopathy (DCM) is a leading cause of heart failure. However, disease-modifying therapies remain limited. Metabolic dysfunction has emerged as a key driver of DCM pathogenesis, and impaired serine biosynthesis, catalyzed by the rate-limiting enzyme phosphoglycerate dehydrogenase (PHGDH), has recently been identified as a potential therapeutic target. Here, we evaluated the therapeutic potential of increasing serine biosynthesis through AAV9-mediated PHGDH gene augmentation in a transgenic TM54 mouse model of DCM with established pathology. Longitudinal echocardiography showed preserved systolic function and prevented ventricular dilatation in TM54 mice treated with AAV9-PHGDH compared to AAV9-GFP controls. Histological analysis revealed reduced myocardial fibrosis and cardiomyocyte hypertrophy in AAV9-PHGDH-treated TM54 hearts, indicating a reversal of pathological remodeling. Metabolic profiling, including targeted metabolomics and in vivo

Indexed as

Cardiomyopathy, DilatedMyocardiumSerineAnimalsDisease Models, AnimalDisease ProgressionGenetic TherapyMaleMiceMice, TransgenicMyocytes, CardiacPhosphoglycerate DehydrogenasePhosphoglycerate DehydrogenaseSerineDilated cardiomyopathyGene therapyMetabolic therapyPHGDHSerine biosynthesis

Identifiers

PMID40975489
PMCPMC12885113

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.