ArticleThe American journal of clinical nutrition2025
Microbiome-related metabolites in early to midpregnancy and risk of fetal growth extremes: a metabolome-wide association study.
Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Early pregnancy metabolomic signatures for child growth trajectories: a prospective metabolome-wide association study.The American journal of clinical nutrition · 2026Article
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10 authors.
Funding
Abstract
backgroundSmall for gestational age (SGA) and large for gestational age (LGA) are fetal growth extremes that predispose an individual to a plethora of short- and long-term adverse health consequences. Perturbations to the intrauterine metabolic milieu and microbiome have been linked to both SGA and LGA. However, the roles of microbiome-related metabolites as the end products of microbial metabolism in fetal growth remain understudied.
objectivesWe aimed to examine the prospective association of microbiome-related metabolites in early to midpregnancy with risk of SGA and LGA.
methodsWe drew a random sample of singleton pregnancies with 140 SGA, 134 LGA, and 140 appropriate for gestational age (AGA) births from the Pregnancy Environment and Lifestyle Study. Untargeted metabolites were measured by gas chromatography/time-of-flight mass spectrometry, reversed-phase liquid chromatography/quadrupole time-of-flight mass spectrometry, and hydrophilic interaction liquid chromatography/quadrupole time-of-flight mass spectrometry using fasting serum collected at gestational weeks (GW) 10-13 and GW 16-19. Chemical enrichment analysis examined the associations of metabolites with SGA and LGA compared with AGA risk, with false discovery rate (FDR) adjustment.
resultsWe detected 135 microbiome-related metabolites. At GW 10-13, clusters of basic amino acids (AAs), branched-chain AAs, and dicarboxylic acids were significantly and positively associated with risk of SGA, after adjusting for covariates and multiple testing (all P
conclusionsThis study identifies common and unique microbiome-related metabolites associated with risk of fetal growth extremes. Given that microbiota is malleable, our findings may inform strategies to optimize the intrauterine microbial-metabolic profile and fetal growth.
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