Evidence map›Paper›PMID 40975129›Full record

ReviewCurrent opinion in insect science2026

Leveraging DNA repair mechanisms in genetically engineered biocontrol.

Joseph S Romanowski, Christian E Ogaugwu, Zach N Adelman

Abstract readReview
In one paragraph

Review in Current opinion in insect science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph S RomanowskiInterdisciplinary Graduate Program in Genetics and Genomics, United States of America.
Christian E OgaugwuDepartment of Entomology, Texas A&M University, College Station, TX 77845, United States of America.
Zach N AdelmanDepartment of Entomology, Texas A&M University, College Station, TX 77845, United States of America. Electronic address: zachadel@tamu.edu.

Funding

Self-Eliminating Strategy To Control Gene DriveR01AI148787 · NIAID · TEXAS A&M AGRILIFE RESEARCH · PI Zach N. Adelman, KEVIN M MYLES · 2020 to 2026
$4.4M
NIAID NIH HHS R01 AI148787
6 · The paper itself

Abstract

Genetic biocontrol strategies such as gene drives are garnering much attention due to the great potential to achieve population control at unprecedented speed and precision. Several endogenous DNA repair pathways can facilitate or counteract the success of gene drives. Current studies focus on HDR and NHEJ pathways and employ various detection and analytical methods to assess editing events due to these DNA repair pathways. However, other DNA repair pathways, such as MMEJ and SSA, could equally be leveraged to design better gene drives. More methods for predicting, detecting, and analyzing editing events due to these diverse pathways are needed. This review explores the currently available tools and packages to assist in this venture.

Indexed as

DNA RepairGene Drive TechnologyGenetic EngineeringInsectaPest Control, BiologicalAnimals

Identifiers

PMID40975129
PMCPMC13247887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.