CPVT1 point mutations in RyR2 S5 and S6 segments and their Ca

Xiao-Hua Zhang, Grace Ellen Donch, Naohiro Yamaguchi, Martin Morad

Abstract read

In one paragraph

Article in Cell calcium, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiao-Hua ZhangCardiac Signaling Center of University of South Carolina, Medical University of South Carolina and Clemson University, USA.

Grace Ellen DonchCardiac Signaling Center of University of South Carolina, Medical University of South Carolina and Clemson University, USA; College of Charleston, Charleston SC, USA.

Naohiro YamaguchiCardiac Signaling Center of University of South Carolina, Medical University of South Carolina and Clemson University, USA; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina.

Martin MoradCardiac Signaling Center of University of South Carolina, Medical University of South Carolina and Clemson University, USA; Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina. Electronic address: moradm@musc.edu.

Funding

Functional implications of CPVT1-associated RyR2 mutations in human cardiomyocytesR01HL153504 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI MORAD, MARTIN, YAMAGUCHI, NAOHIRO · 2021 to 2024

$2.0M

NHLBI NIH HHS R01 HL153504

6 · The paper itself

Abstract

Precise activation of cardiac ryanodine receptor (RyR2) by small influx of Ca

Indexed as

Calcium SignalingPoint MutationRyanodine Receptor Calcium Release ChannelTachycardia, VentricularCaffeineCalciumHumansInduced Pluripotent Stem CellsMyocytes, CardiacPolymorphic Catecholaminergic Ventricular TachycardiaCaffeineCalciumRyanodine Receptor Calcium Release ChannelRyR2 protein, humanCRISPR/Cas9ER-GCaMP6 SR Ca(2+) probehiPSC-CMsR4822H and L4865VRyR2 S5 and S6

Identifiers

PMID40974955

DOI10.1016/j.ceca.2025.103081

PMCPMC13262525

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.