Observational studyUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology2025
Role of aspirin therapy in modulating uterine artery resistance and placental growth between first and second trimesters of pregnancy.
Observational study in Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Plasma RNA-Based Dual Screening for Early/Extreme Spontaneous Preterm Birth and Early Onset Preeclampsia to Enable Prevention.Diagnostics (Basel, Switzerland) · 2026Article
- Low PAPP-A Levels and Growth in Twin Pregnancies.Life (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the impact of low-dose aspirin (LDA) on placental size and uterine artery pulsatility index (UtA-PI) by analyzing longitudinal changes between the first and second trimesters in pregnancies at high risk for early-onset pre-eclampsia (PE).
methodsThis was a prospective observational cohort study of 631 singleton pregnancies. Women at high risk of early-onset PE (delivery ≤ 33 + 6 weeks) were identified using maternal factors or a multivariate screening protocol and were prescribed LDA. Placental size was assessed using two- and three-dimensional ultrasonography, and UtA-PI was measured using transabdominal Doppler, with measurements obtained in the first and second trimesters. Differences in placental measurements and UtA-PI between high-risk women receiving LDA and low-risk untreated women were analyzed.
resultsAmong the 631 participants, 53 (8.4%) women were prescribed LDA for the prevention of early-onset PE. Placental size in the first trimester was significantly smaller in the LDA group compared with the untreated group, as exemplified by placental volume (mean ± SD, 68.46 ± 25.19 cm
conclusionsWomen at high risk for early-onset PE have a smaller placenta and higher UtA-PI in the first and second trimesters. Treatment of high-risk women with LDA did not affect placental growth but was associated with a greater reduction in UtA-PI, suggesting a positive effect of LDA on placental perfusion. These findings provide insight into the mechanism of action of LDA in the prevention of PE. © 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.