ArticleTissue engineering and regenerative medicine2025
Mulberry Silk Worm Pupae Oil and Prussian Blue Nanoparticle Enriched Multi-Faceted Polyvinyl Alcohol Nanofiber for Infectious Full Thickness Skin Wound Healing.
Article in Tissue engineering and regenerative medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- AI-Guided 4D Printing of Carnivorous Plants-Inspired Microneedles for Accelerated Wound Healing.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- The antimicrobial peptide EM86 loaded to gamma-irradiated sodium alginate/polyvinyl alcohol electrospun nanofibrous dressing treated multidrug-resistantFrontiers in bioengineering and biotechnology · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundRecently, electrospun nanofiber composite scaffolds encaged with bioactive agents have gained prominence as an innovative therapy for managing full-thickness infectious wounds.
methodsThis study mainly focuses on the development and comprehensive characterization of multi-component polyvinyl alcohol (PVA)-based nanofiber scaffolds incorporating pupae oil (PO) and Prussian blue nanoparticles (PBNPs) using electrospinning technique for accelerated full thickness infectious wound healing.
resultsScanning electron microscopy (SEM) photographs revealed a porous, interconnected fibrous structure with diameters ranging between 200 and 300 nm. Fourier-transform infrared spectroscopy confirmed the chemical compatibility and successful incorporation of PO and PBNPs into the scaffolds. The scaffolds exhibited optimal biodegradation over a two-week period and demonstrated appropriate water uptake capacity to absorb wound exudates. Furthermore, they displayed potent antibacterial and antibiofilm efficacy against Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa), as well as minimal microbial penetration across nanofiber scaffolds. In vitro studies on L-929 fibroblast cells indicated improved cell viability, migration, cell adhesion, and proliferation. In vivo evaluation in an infected rat model demonstrated rapid wound closure and improved tissue regeneration. Moreover, haematoxylin and eosin (H&E) and masson-trichome staining corroborated the scaffolds' excellent wound healing efficacy. Additionally, enzyme-linked immunosorbent assay demonstrated significant downregulation of key pro-inflammatory markers.
conclusionThese results suggest that the bioinspired, multi-component PVA-based nanofiber scaffolds loaded with natural bioactive agents (PO and PBNPs), hold great potential as a therapeutic strategy for promoting enhanced healing of full-thickness infected wounds.
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