Evidence map›Paper›PMID 40974517›Full record

ArticleMolecular biology reports2025

Exploratory analysis of TNF promoter SNPs and their potential associations with sarcopenia components in older Mexican adults.

Graciela Llanos-Becerra, Rodolfo Iván Valdez-Vega, Oscar Rosas-Carrasco, Norma Torres-Carrillo, Priscila Iveth Ibarra-Montero, Nidia Guadalupe Velasco-Pérez, Raúl Beltrán-Ramírez, Nora Magdalena Torres-Carrillo

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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8 authors.

Graciela Llanos-Becerra *Departamento de Microbiología y Patología Centro de Investigación en Enfermedades Infectocontagiosas, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Rodolfo Iván Valdez-Vega *Departamento de Microbiología y Patología Centro de Investigación en Enfermedades Infectocontagiosas, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Oscar Rosas-CarrascoDepartamento de Salud, Universidad Iberoamericana, Ciudad de México, Mexico.
Norma Torres-CarrilloDepartamento de Microbiología y Patología Centro de Investigación en Enfermedades Infectocontagiosas, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Priscila Iveth Ibarra-MonteroDepartamento de Microbiología y Patología Centro de Investigación en Enfermedades Infectocontagiosas, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Nidia Guadalupe Velasco-PérezDepartamento de Microbiología y Patología Centro de Investigación en Enfermedades Infectocontagiosas, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara, Guadalajara, Jalisco, Mexico.
Raúl Beltrán-RamírezDepartamento de Sistemas de Información, Centro Universitario de Ciencias Económico Administrativas Universidad de Guadalajara, Zapopan, Jalisco, Mexico.
Nora Magdalena Torres-CarrilloDepartamento de Microbiología y Patología Centro de Investigación en Enfermedades Infectocontagiosas, Centro Universitario de Ciencias de la Salud Universidad de Guadalajara, Guadalajara, Jalisco, Mexico. nora.torres@academicos.udg.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConsidering the key role of inflammation in sarcopenia pathogenesis, we focused on tumor necrosis factor (TNF). We examined associations between TNF promoter single-nucleotide polymorphisms (SNPs; rs1799964, rs1799724, and rs361525), individually and as haplotypes, with serum TNF-α levels and sarcopenia in older Mexican adults. METHODS AND

resultsThis cross-sectional study included Mexican adults aged 70 years or older. Sarcopenia was defined using calf circumference as a proxy for muscle mass, plus grip strength and physical performance, according to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. Serum TNF-α was measured by enzyme immunoassay, SNPs were genotyped using TaqMan assays, and haplotypes were estimated using haplo.stats and HAPLOVIEW. Among 223 participants, 45 had sarcopenia. rs1799964 was associated with grip strength in the total sample (OR = 0.08, 95%CI = 0.01-0.86, p = 0.014) and with calf circumference in men (OR = 0.08, 95%CI = 0.01-0.96, p = 0.014). rs1799724 was associated with poor physical performance (OR = 1.88, 95%CI = 1.04-3.37, p = 0.032), as was the TTG haplotype (OR = 1.85, 95%CI = 1.10-3.11, p = 0.019). Serum TNF-α was inversely correlated with Physical Performance (rho= -0.142, p = 0.047).

conclusionsOur findings suggest that TNF promoter SNPs may be associated with specific components of sarcopenia, but not with serum TNF-α levels or the presence of sarcopenia in older Mexican adults. These results are exploratory and should be interpreted with caution, highlighting the need for further research to confirm and clarify these associations.

Indexed as

Polymorphism, Single NucleotidePromoter Regions, GeneticSarcopeniaTumor Necrosis Factor-alphaAgedAged, 80 and overCross-Sectional StudiesFemaleGenetic Association StudiesGenetic Predisposition to DiseaseGenotypeHand StrengthHaplotypesHumansMaleMexicoTNF protein, humanTumor Necrosis Factor-alphaAgingOlder adultsSarcopeniaSNPsTNF-α

Identifiers

PMID40974517

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.