Evidence map›Paper›PMID 40974507›Full record

Observational studyEndocrine2025

Thalassemia-Associated mixed hypogonadism (TAMH): unraveling a unique endocrine pattern and its impact on cardiovascular risk.

Maddalena Casale, Martina Errico, Francesca Allosso, Lucia Digitale Selvaggio, Graziella Grande, Claudia Di Ludovico, Raffaele Navarra, Domenico Roberti, Maria Maddalena Marrapodi, Silverio Perrotta and 1 more

Erratum issuedAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Endocrine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Maddalena CasaleDepartment of Woman, Child and General and Specialized Surgery, University of Campania L. Vanvitelli, Naples, Italy.
Martina ErricoDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.
Francesca AllossoDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.
Lucia Digitale SelvaggioDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.
Graziella GrandeDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.
Claudia Di LudovicoDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.
Raffaele NavarraDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy.
Domenico RobertiDepartment of Woman, Child and General and Specialized Surgery, University of Campania L. Vanvitelli, Naples, Italy.
Maria Maddalena MarrapodiDepartment of Woman, Child and General and Specialized Surgery, University of Campania L. Vanvitelli, Naples, Italy.
Silverio PerrottaDepartment of Woman, Child and General and Specialized Surgery, University of Campania L. Vanvitelli, Naples, Italy.
Daniela PasqualiDepartment of Advanced Medical and Surgical Sciences, University of Campania L. Vanvitelli, Naples, Italy. daniela.pasquali@unicampania.it.ORCID 0000-0002-5674-635X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTransfusion Dependent Thalassemia (TDT) is a hereditary hematologic disorder requiring chronic transfusions, leading to iron overload and frequent endocrinological complications, notably hypogonadism, defined as secondary or hypogonatropic, potentially impacting quality of life and cardiovascular (CV) risk. This study aimed to evaluate the pattern of hypogonadism in TDT and its impact on CV risk compared to non-hypogonadal subjects with TDT and hypogonadal subjects without TDT.

methodsA cross-sectional observational study assessed 22 TDT patients with hypogonadism (H-TDT) and 31 TDT without a diagnosis of hypogonadism (NH-TDT) aged 18 years or older. A control group of adult non-thalassemic hypogonadotropic hypogonadism patients (HH-C) was included for comparison. Data on medical history, clinical signs/symptoms of hypogonadism, lifestyle factors, blood pressure, and hormone levels were collected. CV risk was assessed using Framingham and Progetto Cuore scores, as well as echocardiographic parameters.

resultsH-TDT patients had significantly higher FSH and LH levels than HH-C (p < 0.001). Significant differences in CV and total cholesterol levels were found between TDT patients with and without hypogonadism (p = 0.046, p = 0.004, respectively). CV risk was similar between H-TDT patients and the HH-C.

conclusionsThe nature of hypogonadism in TDT is essentially mixed, definitively transcending a purely hypogonadotropic profile. Furthermore, while the CV risk is higher in subjects with H-TDT compared to NH-TDT, it remains extraordinarily low and not pathological according to two validated scores in the general population. This suggests a need to identify more suitable tools for the CV risk in TDT patients.

Indexed as

Cardiovascular DiseasesHypogonadismThalassemiaAdultCross-Sectional StudiesFemaleFollicle Stimulating HormoneHeart Disease Risk FactorsHumansLuteinizing HormoneMaleMiddle AgedYoung AdultFollicle Stimulating HormoneLuteinizing HormoneCardiovascular riskHypogonadismIron overload.Thalassemia-associated mixed hypogonadismTransfusion-dependent thalassemia

Identifiers

PMID40974507
PMCPMC12708700

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.