Evidence map›Paper›PMID 40974487›Full record

ArticleMolecular diversity2026

Molecular docking-based design of novel tricyclic tetrahydropyridothienopyrimidinone derivatives as AChE/MAO-B dual inhibitors.

Juan Zhang, Yue Li, Jia-Dong Shao, Guo Wei, Nai-Yu Zhang, Kong-Kai Zhu, Kai-Ming Wang, Cheng-Shi Jiang, Jia-Hong Wang

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Juan Zhang *Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310013, Zhejiang, China.
Yue Li *School of Biological Science and Technology, University of Jinan, Jinan, 250022, China.
Jia-Dong Shao *Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Guo Wei *School of Biological Science and Technology, University of Jinan, Jinan, 250022, China.
Nai-Yu ZhangSchool of Biological Science and Technology, University of Jinan, Jinan, 250022, China.
Kong-Kai ZhuAdvanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Kai-Ming WangSchool of Biological Science and Technology, University of Jinan, Jinan, 250022, China. bio_wangkm@ujn.edu.cn.
Cheng-Shi JiangSchool of Biological Science and Technology, University of Jinan, Jinan, 250022, China. bio_jiangcs@ujn.edu.cn.
Jia-Hong WangCenter of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310013, Zhejiang, China. jhongwang89@163.com.

Funding

National Natural Science Foundation of China 82204240Natural Science Foundation of Shandong Province ZR2023MB046
6 · The paper itself

Abstract

The present study describes the design, synthesis, and evaluation of novel tricyclic tetrahydropyridothienopyrimidinone (THPTP) derivatives as dual AChE/MAO-B inhibitors. Building on our previous hit A03, an additional benzyl substituent was added to improve interactions with the peripheral anionic site of AChE and enhance MAO-B binding. The derivatives showed increased inhibitory activities, with compound A03-12 exhibiting significant potency (huAChE: IC

Indexed as

AcetylcholinesteraseCholinesterase InhibitorsDrug DesignMolecular Docking SimulationMonoamine OxidaseMonoamine Oxidase InhibitorsPyrimidinonesAnimalsHumansKineticsStructure-Activity RelationshipAcetylcholinesteraseCholinesterase InhibitorsMonoamine OxidaseMonoamine Oxidase InhibitorsPyrimidinonesAChE/MAO-B dual inhibitorsAlzheimer's diseaseBlood–brain barrier permeabilityMolecular dockingMolecular dynamics simulationsPharmacokinetic profiles

Identifiers

PMID40974487

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.