ArticleEuropean radiology experimental2025
Spectral photon-counting CT in first-pass myocardial perfusion imaging for very high-risk patients: a comparison with dual-energy CT.
Article in European radiology experimental, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- CT-derived myocardial extracellular volume: current evidence, clinical utility, and the emerging role of photon-counting CT-a systematic review.European radiology experimental · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSpectral photon-counting computed tomography (SPCCT) outperformed dual-energy computed tomography (DECT) for coronary artery stenosis assessment. However, data about myocardial perfusion imaging (MPI) is lacking. This feasibility study aimed to evaluate and compare the diagnostic performance of SPCCT and DECT for rest MPI in patients with hemodynamically significant coronary stenoses, using invasive coronary angiography (ICA) and invasive fractional flow reserve (FFR) as reference standards. MATERIALS AND
methodsEighteen very-high-risk patients with hemodynamically significant coronary stenoses at ICA underwent both dual-layer DECT and SPCCT coronary CT within three days. The sensitivity, specificity, and accuracy of MPI in detecting myocardial hypoperfusion were assessed. Quantitative attenuation differences between normal and hypoperfused myocardial segments were compared for both modalities. Interobserver variability was assessed with a weighted kappa analysis.
resultsSPCCT demonstrated comparable overall performance to DECT for MPI, with an overall sensitivity, specificity, and accuracy of 73.3%, 79.2%, and 76.9%, respectively, versus 73.3%, 75%, and 74.4% for DECT. SPCCT outperformed DECT in the left anterior descending artery territory, achieving a sensitivity of 87.5%, specificity of 100%, and accuracy of 90%, versus 62.5%, 50%, and 60% for DECT. For each CT system, attenuation analysis revealed differences between normal and hypoperfused segments, with mean differences of 17.9 HU for DECT and 15.8 HU for SPCCT (p < 0.05). Inter-reader agreement was higher for SPCCT (κ = 0.86) compared to DECT (κ = 0.62).
conclusionSPCCT and DECT provided similar diagnostic performance for rest MPI in a very-high-risk patient cohort, demonstrating comparable effectiveness in detecting the effects of hemodynamically significant coronary stenosis. RELEVANCE STATEMENT: Hemodynamically significant stenosis in very-high-risk patients results in myocardial hypoperfused areas at rest that can be detected equally well with dual-layer CT and spectral photon counting CT, albeit with better reproducibility for the latter. KEY POINTS: SPCCT and DECT showed comparable performance for MPI at rest in very-high-risk patients. The differences between normal and hypoperfused segments were of 17 HU and 16 HU on conventional images for DECT and SPCCT. SPCCT showed higher interobserver agreement compared to DECT, suggesting improved reproducibility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.