Evidence map›Paper›PMID 40974427›Full record

ArticleJournal of muscle research and cell motility2025

LncRNA Xist acts as a miR-486-5p sponge to modulate myoblast proliferation by recruiting Stk4.

Wenlun Wang, Huang Yan, Li Wenbin, Yu Chaohang, Wu Shengcai, Cai Xioqing, Zhou Nanqing, Yuan Qing, Hu Qianmin, Zhang Feng and 1 more

Abstract read
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In one paragraph

Article in Journal of muscle research and cell motility, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenlun Wang *Department of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China. 1019159335@qq.com.
Huang Yan *Department of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China.
Li Wenbin *Department of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China.
Yu Chaohang *Department of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China.
Wu Shengcai *Department of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China.
Cai Xioqing *Department of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China.
Zhou Nanqing *Department of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China.
Yuan QingDepartment of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China.
Hu QianminDepartment of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China.
Zhang FengDepartment of Food Science and Engineering, Moutai Institute, Renhuai,, 564507, Guizhou, China.
Zhu LingyunDepartment of Biology and Chemistry, College of Sciences, National University of Defense Technology, Changsha, 410073, Hunan, China.

Funding

Guizhou Provincial Basic Research Program (Natural Science) QiankeHeJiChu-ZK[2024]-YiBan-659The Natural Science Foundation of Hunan Province, grant number CX20190003the Research Foundation for Scientific Scholars of Moutai Institute, grant number mygccrc[2023]011The Youth Science and Technology Talent Growth Project of Guizhou Province Education Department No. [2024]262
6 · The paper itself

Abstract

Cell proliferation plays a crucial role in muscle atrophy-regeneration. However, the functional roles of Long non-coding RNA X-inactive specific transcript (lncRNA Xist) in C2C12 cell proliferation remain poorly characterized. We identified lncRNA Xist as a regulator of cell proliferation kinetics by acting as a competing endogenous RNA (ceRNA) in C2C12 cells. Downregulation or overexpression of lncRNA Xist correlated with enhanced or impaired cell proliferation, respectively. Mechanistically, lncRNA Xist sponges miR-486-5p to regulate serine/threonine kinase 4 (Stk4) expression, thereby modulating C2C12 cell proliferation in vitro. The lncRNA Xist/miR-486-5p/Stk4 ceRNA network plays an essential role in C2C12 proliferation, suggesting lncRNA Xist as a potential therapeutic target for muscle atrophy.

Indexed as

Cell ProliferationMicroRNAsMyoblastsProtein Serine-Threonine KinasesRNA, Long NoncodingAnimalsCell LineHumansMiceMicroRNAsProtein Serine-Threonine KinasesRNA, Long NoncodingXIST non-coding RNACell proliferationLncRNA xistMiR-486-5pSkeletal muscleStk4

Identifiers

PMID40974427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.