Evidence map›Paper›PMID 40974424›Full record

ArticleMetabolic brain disease2025

Umbelliferone reverses neuronal damage induced by chronic Chlorpyrifos exposure via suppressing NF-κB/STAT3/NLRP3 and boosting Keap-1/Nrf2/HO-1 signals.

Salwa Fares Ahmed, Tarek Hamdy Abd-Elhamid, Sarah Abdulaziz Alamer, Mohammad Bani Ismail, Fares E M Ali, Emad H M Hassanein, Hanan S Althagafy, Amany Refaat Mahmoud

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Salwa Fares AhmedDepartment of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Tarek Hamdy Abd-ElhamidDepartment of Histology and Cell Biology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.
Sarah Abdulaziz AlamerDepartment of Biological Sciences, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.
Mohammad Bani IsmailDepartment of Basic Medical Sciences, Faculty of Medicine, Aqaba Medical Sciences University, Aqaba, 77110, Jordan.
Fares E M AliDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Assiut Branch, Al-Azhar University, Assiut, 71524, Egypt. Faresali@azhar.edu.eg.
Emad H M HassaneinDepartment of Pharmacology & Toxicology, Faculty of Pharmacy, Assiut Branch, Al-Azhar University, Assiut, 71524, Egypt.
Hanan S AlthagafyDivision of Biochemistry, Department of Biological Sciences, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
Amany Refaat MahmoudDepartment of Human Anatomy and Embryology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chlorpyrifos (CPF), an organophosphate pesticide, is a widely used pest control chemical. Unfortunately, pesticides are known to cause neuronal intoxication. Umbelliferone (UMB) is an antioxidant, anti-inflammatory, and neuroprotective phytochemical. We plan to investigate the effectiveness of UMB in treating CPF-induced neurotoxicity. In our investigation, rats were assigned to the control, 30 mg/kg of UMB, 10 mg/kg of untreated CPF, CPF + UMB (15 mg/kg), and CPF + UMB (30 mg/kg) groups. UMB reduced neuronal intoxication by lowering p-Tau/Tau and β-amyloid. UMB reduced CPF-induced neuronal oxidative damage by lowering MDA content and increasing GSH levels, mediated by downregulating Keap1 and upregulating Nrf2, HO-1, and SOD3. UMB decreased CPF-induced brain inflammation by lowering TNF-α and IL-6 levels by suppressing NF-κB and STAT3 activation and downregulating NLRP3 dose-dependently. Our findings indicated that UMB is a potentially effective treatment approach for reducing CPF-induced neuronal intoxication by restoring the balance between oxidants and antioxidants and reducing inflammatory responses in brain tissues.

Indexed as

ChlorpyrifosNeuronsNeuroprotective AgentsUmbelliferonesAnimalsAntioxidantsHeme Oxygenase (Decyclizing)InsecticidesKelch-Like ECH-Associated Protein 1MaleNF-E2-Related Factor 2NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressRatsRats, Sprague-Dawley7-hydroxycoumarinAntioxidantsChlorpyrifosHeme Oxygenase (Decyclizing)Hmox1 protein, ratInsecticidesKEAP1 protein, ratKelch-Like ECH-Associated Protein 1Neuroprotective AgentsNfe2l2 protein, ratNF-E2-Related Factor 2NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratStat3 protein, ratSTAT3 Transcription FactorUmbelliferonesAudioVolumeDownChlorpyrifosKeap1/Nrf2/ARENF-κB/STAT3/NLRP3Umbelliferone

Identifiers

PMID40974424

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.