Evidence map›Paper›PMID 40974371›Full record

SynthesisAlimentary pharmacology & therapeutics2025

Meta-Analysis: Mortality Trends and Risk Factors in Severe Alcohol-Associated Hepatitis.

Mushfiqur R Siddique, Muzzafar Haque, Francisco Idalsoaga, Luis Antonio Diaz, Gene Im, Ashwani K Singal, Stephen Hoang, Mohammad Qasim Khan, Juan Pablo Arab

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Alimentary pharmacology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mushfiqur R SiddiqueDepartment of Internal Medicine, Jamaica Hospital Medical Center, New York, USA.
Muzzafar HaqueDepartment of Internal Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Canada.
Francisco IdalsoagaDivision of Gastroenterology, Department of Medicine, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0001-5607-0698
Luis Antonio DiazDepartment of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-8540-4930
Gene ImCenter for Liver Disease and Transplantation, Columbia University, Vagelos College of Physicians and Surgeons, New York, USA.ORCID https://orcid.org/0000-0003-0009-8418
Ashwani K SingalDepartment of Gastroenterology, Hepatology and Nutrition, University of Louisville School of Medicine and University of Louisville Alcohol Research Center, Louisville, Kentucky, USA.ORCID https://orcid.org/0000-0003-1207-3998
Stephen HoangStravitz-Sanyal Institute for Liver Disease and Metabolic Health, Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-4413-6036
Mohammad Qasim KhanDivision of Gastroenterology, Department of Medicine, Western University, London, Ontario, Canada.ORCID https://orcid.org/0000-0002-3457-7858
Juan Pablo ArabDepartment of Gastroenterology, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0000-0002-8561-396X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSevere alcohol-associated hepatitis (sAH) is a life-threatening condition. Despite advances in clinical management, prognosis remains poor and long-term effectiveness of available therapies is uncertain. We conducted a systematic review and meta-analysis to evaluate short-term mortality (28, 60, and 90-day) trends in sAH over the past five decades.

methodsWe searched PubMed, EMBASE, and Scopus from database inception to February 2024 for studies reporting 28, 60, and 90-day mortality in patients with sAH. Pooled mortality estimates were calculated using a random-effects meta-regression model. We assessed heterogeneity using the I

results34 studies comprising 1586 patients with sAH were included. Pooled mortality rates were 26.8% (95% CI: 21.0%-33.5%) at 28 days, 35.1% (95% CI: 28.3%-42.5%) at 60 days, and 43.7% (95% CI: 34.6%-53.3%) at 90 days. Mortality increased steadily with follow-up time. Substantial heterogeneity was observed, as expected in pooled proportion meta-analysis (I

conclusionsShort-term mortality in sAH remains high and has not improved in recent decades. These findings highlight the urgent need for effective therapies, improved patient selection for early liver transplantation, and better prognostic tools to guide clinical decision-making.

Indexed as

Hepatitis, AlcoholicBayes TheoremHumansRisk FactorsSeverity of Illness Indexalcoholalcohol‐associated liver diseasealcoholic cirrhosisalcoholic hepatitisalcoholic liver diseasemeta analysismortalitysystematic review

Identifiers

PMID40974371
PMCPMC12517119

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.