SynthesisMayo Clinic proceedings2025
The Genetic Associations Between Kidney Stones, Obesity, Type 2 Diabetes, and Hypertension.
Synthesis in Mayo Clinic proceedings, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Gut microbiota: a novel key player in urinary stone formation - from oxalate metabolism to systemic regulation.Gut microbes · 2026Review
- Machine learning-driven multi-omics integration of urinary organic acids and ions enables precision risk stratification for calcium oxalate nephrolithiasis.Frontiers in medicine · 2026Article
- FTO in cardiovascular diseases: mechanisms, context dependence, and translational opportunities.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectiveInvestigate shared genetic changes that contribute to the association of kidney stones with cardiometabolic comorbidities. PATIENTS AND
methodsGenome-wide association studies (GWAS) and meta-analyses were performed using the UK Biobank, Mayo Clinic Biobank, and FinnGen, complemented by secondary genetic association analyses.
resultsGenetic correlation analyses confirmed modest but significant positive associations between kidney stones and hypertension, obesity, and type 2 diabetes (r
conclusionOur study highlights a critical role for shared obesity-related genetic changes in the comorbid relationship between kidney stones and cardiometabolic conditions. There are additional genetic features related to thyroid function that are shared between kidney stones and type 2 diabetes, which appear to be independent of obesity.
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