Evidence map›Paper›PMID 40974262›Full record

Observational studyMultiple sclerosis (Houndmills, Basingstoke, England)2025

Disease course after pregnancy in women with progressive multiple sclerosis symptoms.

Jessica Shipley, Heidi N Beadnall, Paul G Sanfilippo, Dana Horakova, Cavit Boz, Alexandre Prat, Serkan Ozakbas, Tomas Kalincik, Izanne Roos, Ayse Altintas and 10 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Multiple sclerosis (Houndmills, Basingstoke, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jessica ShipleyDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0003-2988-7525
Heidi N BeadnallBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Paul G SanfilippoDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Dana HorakovaDepartment of Neurology and Center of Clinical Neuroscience, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.ORCID 0000-0003-1915-0036
Cavit BozDepartment of Neurology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.
Alexandre PratCentre hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montreal, QC, Canada.
Serkan OzakbasIzmir University of Economics, Medical Point Hospital, Izmir, Turkey.
Tomas KalincikNeuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC, Australia.ORCID 0000-0003-3778-1376
Izanne RoosNeuroimmunology Centre, Department of Neurology, Royal Melbourne Hospital, Melbourne, VIC, Australia.ORCID 0000-0003-0371-3666
Ayse AltintasDepartment of Neurology, School of Medicine and Koç University Research Center for Translational Medicine (KUTTAM), Koç University, School of Medicine, Istanbul, Turkey.
Sara EichauDepartment of Neurology, Hospital Universitario Virgen Macarena, Seville, Spain.
Olga SkibinaDepartment of Neurology, Alfred Health, Melbourne, VIC, Australia.
Raed AlroughaniDivision of Neurology, Department of Medicine, Amiri Hospital, Sharq, Kuwait.
Francesco PattiDepartment of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Catania, Italy.ORCID 0000-0002-6923-0846
Masoud EtemadifarDepartment of Neurology, Dr. Etemadifar MS Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
Alessandra LugaresiDipartimento di Scienze Biomedieche e Neuromotorie, Università di Bologna, Bologna, Italia.ORCID 0000-0003-2902-5589
Valentina TomassiniInstitute for Advanced Biomedical Technologies (ITAB), Department of Neurosciences, Imaging and Clinical Sciences, University G. d'Annunzio of Chieti-Pescara, Chieti, Italy.
Helmut ButzkuevenDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.
Anneke van der WaltDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-4278-7003
Vilija G JokubaitisDepartment of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-3942-4340

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe impact of pregnancy on disease outcomes has not been characterised in women with progressive multiple sclerosis (MS) phenotypes. This study aimed to describe the clinical characteristics and disease course of women who experienced a pregnancy after a diagnosis of primary progressive MS (PPMS) or secondary progressive MS (SPMS).

methodsThis multicentre observational cohort study utilised data from the international MSBase Registry extracted on 2 June 2024. Expanded Disability Status Scale (EDSS) scores of women with progressive MS were assessed up to 10 years postpartum and compared to those of propensity score-matched women with progressive MS without a pregnancy history.

resultsIn total, 138 women with 164 pregnancies were included in the study, comprising 75 women with PPMS and 63 with SPMS. Of these, 24 women with PPMS and 47 with SPMS had longitudinal peri-pregnancy EDSS assessments and were included in the analysis of disability scores. A history of pregnancy was not associated with a significant difference in long-term disability trajectories in women with either PPMS (estimate = -0.02; 95% confidence interval (CI) = -0.07 to 0.04) or SPMS (estimate = 0.00; 95% CI = -0.02 to 0.03).

conclusionA history of pregnancy is not associated with a significant difference in long-term disability in women with progressive MS symptoms.

Indexed as

Disease ProgressionMultiple Sclerosis, Chronic ProgressivePregnancy ComplicationsAdultCohort StudiesDisability EvaluationFemaleHumansMiddle AgedPostpartum PeriodPregnancyRegistriesclinical outcomesdisabilityMultiple sclerosispregnancyprimary progressive multiple sclerosissecondary progressive multiple sclerosis

Identifiers

PMID40974262
PMCPMC12547043

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.