Evidence map›Paper›PMID 40974238›Full record

ArticleJPEN. Journal of parenteral and enteral nutrition2025

Body composition in patients with obesity-related heart failure with preserved ejection fraction: A comparison study.

Hannah Salmons, Syed Imran Ahmed, Hayley E Billingsley, Alexander Reavey-Cantwell, Roshanak Markley, Michele Golino, Marco Giuseppe Del Buono, Juan Ignacio Damonte, Sebastian Pinel, R Lee Franco and 3 more

Abstract readComparative Study
In one paragraph

Article in JPEN. Journal of parenteral and enteral nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hannah SalmonsDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Syed Imran AhmedDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Hayley E BillingsleyDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Alexander Reavey-CantwellDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Roshanak MarkleyPauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Michele GolinoPauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0003-0141-0127
Marco Giuseppe Del BuonoDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Rome, Italy.
Juan Ignacio DamonteHospital Universitario Austral, Pilar, Argentina.
Sebastian PinelHospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
R Lee FrancoDepartment of Kinesiology & Health Sciences, College of Humanities & Sciences, Virginia Commonwealth University, Richmond, Virginia, USA.
Antonio AbbateRobert M. Berne Cardiovascular Research Center, and Division of Cardiology, University of Virginia, Charlottesville, Virginia, USA.
Carrie P EarthmanDepartment of Health Behavior and Nutrition Sciences, University of Delaware, Newark, Delaware, USA.
Salvatore CarboneNutrition Program, EVMS School of Health Professions, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA.ORCID https://orcid.org/0000-0002-8163-0527

Funding

This study was partially supported by a Career Development Award 19CDA34660318 from the American Heart Association to Salvatore Carbone
6 · The paper itself

Abstract

backgroundAppendicular lean mass index is a major determinant of cardiorespiratory fitness in patients with obesity-related heart failure with preserved ejection fraction (HFpEF). Moreover, appendicular lean mass index can be used to diagnose sarcopenia and sarcopenic obesity in this population. We aimed to validate the ability of segmental single-frequency bioelectrical impedance analysis (SF-BIA) to assess body composition compared with dual-energy x-ray absorptiometry (DXA) in patients with HFpEF and obesity, with a focus on appendicular lean mass index for its critical role in diagnosing sarcopenia and sarcopenic obesity.

methodsWe analyzed 62 euvolemic patients from a heart failure outpatient clinic with persistent obesity-related HFpEF (83.8% women, 60.8 ± 2.8 years of age). We used DXA and segmental SF-BIA.

resultsStrong correlations were found between segmental SF-BIA and DXA for appendicular lean mass index (r = 0.897), appendicular fat mass index (r = 0.864), fat mass (r = 0.968), fat mass percentage (r = 0.867), fat-free mass (r = 0.954), fat-free mass percentage (r = 0.852), fat mass index (r = 0.97), and fat-free mass index (r = 0.88) (all p < 0.001), without significant proportional bias for all parameters, except for appendicular fat mass index.

conclusionsSegmental SF-BIA-measured body composition shows strong correlations, appropriate agreements, and no proportional bias compared with DXA. Segmental SF-BIA should be considered in patients with obesity-related HFpEF.

Indexed as

Body CompositionHeart FailureObesityStroke VolumeAbsorptiometry, PhotonAgedBody Mass IndexElectric ImpedanceFemaleHumansMaleMiddle AgedSarcopeniaBIAbody compositionDXAheart failureHFpEFobesity

Identifiers

PMID40974238
PMCPMC12581478

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