Evidence map›Paper›PMID 40974196›Full record

ReviewCell transplantation

Impact of cigarette smoke on the functions of mesenchymal stem cells.

Dragica Pavlovic, Dragana Papic, Danijela Niciforovic, Vladislav Volarevic

Abstract readReview
In one paragraph

Review in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Human Primary Mesenchymal Stem Cells Fail to Recover Full Osteogenic Differentiation Potential Following Washout of Electronic Cigarette Aerosol Extracts.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dragica PavlovicDepartment of Genetics, Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.ORCID 0000-0002-7474-7495
Dragana PapicDepartment of Genetics, Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Danijela NiciforovicCenter for Internal Oncology, University Clinical Center Kragujevac, Kragujevac, Serbia.
Vladislav VolarevicDepartment of Genetics, Center for Harm Reduction of Biological and Chemical Hazards, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.ORCID 0000-0001-5948-9902

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite extensive research and increased public awareness regarding the adverse health effects of tobacco, the prevalence of cigarette smoking continues to rise, resulting in millions of annual deaths attributed to its use. Consistently, cigarette smoke contains harmful toxins that adversely affect all organs, tissues, and cells. As regenerative medicine is developing with the successful application of mesenchymal stem cells (MSCs) in numerous diseases, it is mandatory to elaborate on the factors that may impair or change the regenerative potential of MSCs. It is well established that cigarette smoke negatively affects the function of MSCs; this impairment has critical implications for regenerative medicine, which emphasizes the need to consider patient smoking history prior to application of MSCs. The review elaborates on primary toxic compounds of cigarette smoke as well as its impact on MSC functions such as proliferation and viability, migratory potential, differentiation, and finally immunomodulation, suggesting avenues for further research.

Indexed as

Cigarette SmokingMesenchymal Stem CellsSmokeAnimalsCell DifferentiationCell ProliferationHumansSmokecigarette smokeconventional cigarettesdifferentiationimmunomodulationmesenchymal stem cellsproliferationregenerative medicinetoxicityviability

Identifiers

PMID40974196
PMCPMC12450267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.