Trial reportMolecular nutrition & food research2025
Effect of the Food Matrix on the Survival to the Gastrointestinal Transit of Lacticaseibacillus rhamnosus CRL1505: A Randomized, Controlled, Crossover Study.
Trial report in Molecular nutrition & food research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effect of the Food Matrix on the Survival to the Gastrointestinal Transit of Lacticaseibacillus rhamnosus CRL1505: A Randomized, Controlled, Crossover Study.Molecular nutrition & food research · 2025Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Probiotic survival is crucial for their beneficial effect, but only a few studies have assessed the impact of delivery format on probiotic viability after passage through the gastrointestinal tract.Our study aimed to investigate the survival of Lacticaseibacillus rhamnosus (L. rhamnosus) CRL1505 through the gastrointestinal transit in healthy volunteers after a daily consumption of at least 1 billion CFUs per day administered as freeze-dried cells or incorporated into oat- and milk-fermented drinks. The probiotic's survival was evaluated by combining culture-based and molecular techniques. Our findings revealed that L. rhamnosus CRL1505 survival was significantly higher when the probiotic was administered as an oat- and as a milk-fermented drink. The study highlighted the persistence of CRL1505 in a subset of volunteers 1 week after the last administration. The metataxonomic analysis of fecal samples did not reveal significant changes in microbiota diversity among treatment groups, as expected after probiotic administration in healthy subjects.The survival of CRL1505 through the human gastrointestinal tract was demonstrated with and without the protection of food matrices, highlighting the strain's remarkable ability to withstand harsh conditions. Our findings emphasize the importance of food matrix selection for improving probiotic viability and its potential efficacy in functional foods.
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Registered trials
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