Evidence map›Paper›PMID 40974050›Full record

ArticleThe journal of gene medicine2025

Marine-Derived Enteromorpha prolifera Polysaccharides Suppress Castration-Resistant Prostate Cancer via Akt1 Inhibition.

Pingfa Lin, Na Yao, Tingting Lin, Yanhui Zou, Weiling Lin, Yong Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of gene medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pingfa LinSchool of Pharmacy, Fujian Health College, Fuzhou, Fujian, China.
Na YaoDepartment of Medical Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Tingting LinSchool of Pharmacy, Fujian Medical University, Fuzhou, Fujian, China.
Yanhui ZouSchool of Pharmacy, Fujian Health College, Fuzhou, Fujian, China.
Weiling LinSchool of Pharmacy, Fujian Health College, Fuzhou, Fujian, China.
Yong LinSchool of Pharmacy, Fujian Health College, Fuzhou, Fujian, China.ORCID 0009-0004-1922-8213

Funding

Program for Ocean Economic Development in Fujian Province FJHJF-L-2021-7Science Fund from the Health Commission of Fujian 2023GGB04
6 · The paper itself

Abstract

Prostate cancer remains a leading cause of cancer-related mortality, with castration-resistant and metastatic forms posing significant therapeutic challenges. Marine-derived polysaccharides from Enteromorpha prolifera (EP) have emerged as promising anticancer agents due to their unique bioactive properties. In this study, we investigated the antitumor effects of EP on prostate cancer cells and elucidated its underlying molecular mechanisms. EP demonstrated selective cytotoxicity against aggressive DU145 prostate cancer cells. Mechanistically, EP induced G1/S cell cycle arrest, suppressed DNA synthesis, and inhibited epithelial-mesenchymal transition. Cellular thermal shift assays confirmed EP-Akt1 interaction, increasing the thermal stability of Akt1. These findings establish EP as a novel Akt1-targeting agent that simultaneously blocks proliferative and metastatic pathways in prostate cancer. In conclusion, our results highlight the therapeutic potential of EP as a multitargeted, marine-derived compound for prostate cancer treatment.

Indexed as

Antineoplastic AgentsPolysaccharidesProstatic Neoplasms, Castration-ResistantProto-Oncogene Proteins c-aktUlvaApoptosisCell Line, TumorCell ProliferationEdible SeaweedsEpithelial-Mesenchymal TransitionHumansMaleAKT1 protein, humanAntineoplastic AgentsPolysaccharidesProto-Oncogene Proteins c-aktAkt1 inhibitioncell cycle arrestEnteromorpha prolifera polysaccharidesepithelial‐mesenchymal transitionprostate cancer

Identifiers

PMID40974050
PMCPMC12451855

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.