Evidence map›Paper›PMID 40973997›Full record

ArticleContact dermatitis2026

Contact Allergy in Children in Europe: A Proposal for a Paediatric European Baseline Series.

Anne Birgitte Simonsen, Thomas Rustemeyer, Suzana Ljubojevicé Hadzavdic, Radoslaw Spiewak, Anna Belloni Fortina, Margarida Gonçalo, Ana Maria Giménez Arnau, Nidia Planella-Fontanillas, Marie L A Schuttelaar, Heinrich Dickel and 9 more

Abstract readMulticenter Study
In one paragraph

Article in Contact dermatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Anne Birgitte SimonsenNational Allergy Research Centre, Department of Allergy, Skin and Venerology, Gentofte Hospital, Gentofte Hospitalsvej 20A, Hellerup, University of Copenhagen, Institute of Clinical Medicine Denmark, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-9299-0317
Thomas RustemeyerDepartment of Dermatology-Allergology and Occupational Dermatology, Amsterdam University Medical Center, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-7580-0684
Suzana Ljubojevicé HadzavdicUniversity Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, Zagreb, Croatia.ORCID https://orcid.org/0000-0002-3640-9567
Radoslaw SpiewakDepartment of Experimental Dermatology and Cosmetology, Jagiellonian University Medical College, Krakow, Poland.ORCID https://orcid.org/0000-0001-5968-0555
Anna Belloni FortinaPaediatric Dermatology Regional Center, Department of Woman's and Child's Health SDB, University of Padua, Padua, Italy.ORCID https://orcid.org/0000-0001-5791-0775
Margarida GonçaloDepartment of Dermatology, University Hospital, Coimbra Local Health Unit and Faculty of Medicine, University of Coimbra, Coimbra, Portugal.ORCID https://orcid.org/0000-0001-6842-1360
Ana Maria Giménez ArnauDepartment of Dermatology, Hospital del Mar Research Institute, Universitat Pompeu Fabra, Barcelona, Spain.ORCID https://orcid.org/0000-0001-5434-7753
Nidia Planella-FontanillasDepartment of Dermatology, Hospital del Mar Research Institute, Universitat Pompeu Fabra, Barcelona, Spain.ORCID https://orcid.org/0009-0007-1303-2422
Marie L A SchuttelaarDepartment of Dermatology, University of Groningen, Groningen, the Netherlands.ORCID https://orcid.org/0000-0002-0766-4382
Heinrich DickelDepartment of Dermatology, Venereology and Allergology, St. Josef Hospital, University Medical Center, Ruhr University Bochum, Bochum, Germany.ORCID https://orcid.org/0000-0001-6837-4402
Jonathan WhiteEcole de Sante Publique, Université Libre de Bruxelles, Belgium.ORCID https://orcid.org/0000-0001-7164-2658
Györgyi PónyaiDepartment of Dermatology, Venerology and Dermato-Oncology, Semmelweis University, Budapest, Hungary.ORCID https://orcid.org/0000-0002-1695-6133
S Mark WilkinsonDermatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.ORCID https://orcid.org/0000-0001-7253-3461
Esen ÖzkayaIstanbul University, Istanbul Faculty of Medicine, Department of Dermatology and Venereology, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-9585-9509
Ella DendoovenDepartment of Dermatology, University Hospital Antwerp (UZA) and Research Group Immunology, University of Antwerp, Antwerp, Belgium.ORCID https://orcid.org/0000-0002-3489-8010
Nives PustišekChildren's Hospital Zagreb, Department of Paediatrics, Zagreb, Croatia.ORCID https://orcid.org/0000-0002-2401-9238
Jeanne Duus JohansenNational Allergy Research Centre, Department of Allergy, Skin and Venerology, Gentofte Hospital, Gentofte Hospitalsvej 20A, Hellerup, University of Copenhagen, Institute of Clinical Medicine Denmark, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-3537-8463
Olivier AertsDepartment of Dermatology, University Hospital Antwerp (UZA) and Research Group Immunology, University of Antwerp, Antwerp, Belgium.ORCID https://orcid.org/0000-0002-0076-2887
European Baseline Series (EBS) Working Party of the European Society of Contact Dermatitis (ESCD)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundContact allergy is common in children, but no paediatric baseline series (pEBS) exists in Europe, despite recommendations in several countries.

objectivesTo collect and compare patch testing data from European centres to propose a common pEBS, possibly adapted by age group. MATERIALS AND

methodsData from 13 centres in 12 European countries were aggregated, covering 1816 children (1099 girls, 60.5%), aged 0-16 years, tested with the adult EBS (aEBS) and other frequent allergens between 2018 and 2022. Allergen selection followed adult criteria, with a stricter cut-off for inclusion, requiring at least 1% positive reactions (lower 95% CI) in children.

resultsA total of 17 allergens from the aEBS caused positive reactions in ≥ 1% of children (lower 95% CI). Common allergens included metals, fragrances, and preservatives. Tixocortol-21-pivalate was included despite its lower frequency due to its difficult-to-suspect nature. Additional frequent allergens were hydroperoxides of limonene and linalool, Amerchol L-101, and sorbitan sesquioleate. In total, 18 allergens were identified as potentially qualifying for a pEBS, with a further 7 as recommended additions.

conclusionResults from patch testing children across europe highlight a common set of frequent allergens, which should be considered for a pEBS.

Indexed as

AllergensDermatitis, Allergic ContactPatch TestsAdolescentChildChild, PreschoolEuropeFemaleHumansInfantInfant, NewbornMaleAllergensbaseline serieschildrencontact allergenspatch testing

Identifiers

PMID40973997
PMCPMC12695515

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.