Evidence map›Paper›PMID 40973980›Full record

Trial reportPsycho-oncology2025

Cognitive Behavioral Therapy for Cancer-Related Fatigue: A Comparison Between Patients Treated With Curative Intent and Patients With Advanced Cancer.

Hannah B van der Pas, Annemarie M J Braamse, Gijs Bleijenberg, Hanneke W M van Laarhoven, Pythia Nieuwkerk, Harm Westdorp, Lia van Zuylen, Fabiola Müller, Hans Knoop

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psycho-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Asthenia in cancer patients receiving immune checkpoint Inhibitors (ICIs): the MOUSEION-11 systematic review and meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hannah B van der PasDepartment of Medical Psychology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands.ORCID 0009-0000-2992-706X
Annemarie M J BraamseDepartment of Medical Psychology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands.
Gijs BleijenbergRadboudumc, Department of Medical Psychology, Nijmegen, the Netherlands.
Hanneke W M van LaarhovenCancer Treatment and Quality of Life, Cancer Center Amsterdam, Amsterdam, the Netherlands.
Pythia NieuwkerkDepartment of Medical Psychology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands.
Harm WestdorpRadboudumc, Department of Medical Oncology, Nijmegen, the Netherlands.
Lia van ZuylenCancer Treatment and Quality of Life, Cancer Center Amsterdam, Amsterdam, the Netherlands.
Fabiola MüllerDepartment of Medical Psychology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands.
Hans KnoopDepartment of Medical Psychology, Amsterdam UMC Location University of Amsterdam, Amsterdam, the Netherlands.

Funding

KWF Kankerbestrijding 14890
6 · The paper itself

Abstract

backgroundCancer-related fatigue (CRF) is prevalent in patients who have been treated with curative intent and patients with advanced cancer. Cognitive behavioral therapy (CBT) has been shown effective in reducing CRF in both groups.

aimsTo compare both groups with respect to: (1) pre-treatment levels of fatigue and fatigue-perpetuating cognitive-behavioral factors; (2) the magnitude of the effect of CBT on fatigue; and (3) mediators of the treatment response.

methodsData of four randomized controlled trials testing the efficacy of CBT for CRF were pooled, three in patients treated with curative intent (n = 249), and one in patients with advanced cancer (n = 134). Baseline characteristics were compared with ANCOVAs. Moderation analysis was used to investigate whether the treatment effect differed between groups. With moderated mediation analyses differences in the mechanisms by which CBT reduces fatigue were evaluated.

resultsThe two groups differed significantly at baseline on fatigue-perpetuating factors, but not on fatigue severity. Patients with advanced cancer reported a smaller decrease in fatigue severity following CBT than patients treated with curative intent (p = 0.022). The multivariate moderated mediation analysis showed a larger decrease in fatigue catastrophizing in patients treated with curative intent than in patients with advanced cancer.

conclusionCBT for CRF has less effect on catastrophizing, a known fatigue-perpetuating factor and mediator of the effect of CBT, and fatigue severity in patients with advanced cancer. Further research has to determine if the effectiveness of CBT for CRF in advanced cancer patients can be improved.

Indexed as

Cognitive Behavioral TherapyFatigueNeoplasmsAdultAgedCatastrophizationFemaleHumansMaleMiddle AgedRandomized Controlled Trials as TopicSeverity of Illness IndexTreatment Outcomeadvanced cancercancercancer‐related fatiguecancer survivorscognitive‐behavioral therapyoncologypalliative care

Identifiers

PMID40973980
PMCPMC12449572

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.